Publication: Pathology and terminology of interstitial cystitis/bladder pain syndrome: A review
Authors
Akiyama, Yoshiyuki ; Homma, Yukio ; Maeda, Daichi
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-18-028
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info:eu-repo/semantics/article
Description
Abstract
Interstitial cystitis/bladder pain syndrome
(IC/BPS) is an umbrella term of chronic debilitating
conditions of unknown etiology characterized by
symptoms of lower urinary tract hypersensitivity such as
bladder pain/discomfort, urgency, and urinary frequency.
The pathological features of IC/BPS have been generally
reported as non-specific chronic inflammatory changes,
with mast cell infiltration as a potential key finding.
However, growing evidence reveals a histological
distinction between IC/BPS with Hunner lesions and
IC/BPS without Hunner lesions, and also sheds doubt on
the diagnostic value of the mast cell count. Specifically,
IC/BPS with Hunner lesions is an inflammatory disorder
characterized by pancystitis with B cell abnormalities
and epithelial denudation, while IC/BPS without Hunner
lesions shows minimal histological changes. The
umbrella term “IC/BPS” connects totally distinct clinical
entities. Pathological evaluation thus plays an important
role in the precise subtyping and clinical management of
IC/BPS. In addition, terminology should be developed to
refer separately to IC/BPS with Hunner lesions and
IC/BPS without Hunner lesions
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Citation
Histology and Histopathology, Vol.34, nº1, (2019)
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