Membrane peroxidation index and maximum lifespan are negatively correlated in fish of genus Nothobranchius

de Costa J.; Barja G.; Almaida Pagán, Pedro Francisco

Publication:
Membrane peroxidation index and maximum lifespan are negatively correlated in fish of genus Nothobranchius

dc.contributor.author	de Costa J.
dc.contributor.author	Barja G.
dc.contributor.author	Almaida Pagán, Pedro Francisco
dc.contributor.department	Fisiología
dc.date.accessioned	2021-02-11T12:48:06Z
dc.date.available	2021-02-11T12:48:06Z
dc.date.issued	2020-04-22
dc.description.abstract	Lipid composition of cell membranes is linked to metabolic rate and lifespan in mammals and birds but very little information is available for fishes. In this study, three fish species of the short-lived annual genus Nothobranchius with different maximum lifespan potentials (MLSP) and the longer-lived outgroup species Aphyosemion australe were studied to test whether they conform to the predictions of the longevity-homeoviscous adaptation (LHA) theory of aging. Lipid analyses were performed in whole fish samples and peroxidation indexes (PIn) for every PL class and for the whole membrane, were calculated. Total PL content was significantly lower in A. australe and N. korthausae, the two species with the highest MLSP, and a negative correlation between membrane total PIn and fish MLSP was found, this meaning that the longer-lived fish species have more saturated membranes and therefore, a lower susceptibility to oxidative damage, as the LHA theory posits	es
dc.format	application/pdf	es
dc.format.extent	16	es
dc.identifier.citation	Journal of Experimental Biology, 20, 223, jeb224063, 1-5
dc.identifier.doi	http://dx.doi.org/10.1242/jeb.224063
dc.identifier.issn	1477-9145
dc.identifier.uri	http://hdl.handle.net/10201/103088
dc.language	eng	es
dc.publisher	The Company of Biologists Ltd	es
dc.relation	Proyecto nacional y regional. Agencia/entidad financiadora: Spanish Ministerio de Economia y Competitividad, the Instituto de Salud Carlos III through CIBERFES (CB16/10/00239), the Séneca Foundation through grant 19899/GERM/15 and the Spanish Ministerio de Ciencia, Innovacion y Universidades (RTI2018-093528-B-I00), all of them co-financed by FEDER. Convocatoria: 2016. Nombre del proyecto: CIBERFES: CIBER de Fragilidad y Envejecimiento Saludable y Influence of chronodisruption on human and animal health (CRONOHEALTH)	es
dc.relation.publisherversion	https://jeb.biologists.org/content/223/11/jeb224063	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 España	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/es/	*
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología	es
dc.title	Membrane peroxidation index and maximum lifespan are negatively correlated in fish of genus Nothobranchius	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es