Publication: Comparative study of tumor angiogenesis and immunohistochemistry for p53, c-ErbB2, c-myc and EGFr as prognostic factors in gastric cancer
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Date
2000
Authors
Sanz Ortega, J. ; Steinberg, S.M. ; Moro, E. ; Saez, M. ; Lopez, J.A. ; Sierra, E. ; Sanz Esponera, J. ; Merino, M.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Gastric cancer (GC) continues to be a highly
aggressive malignancy with poor prognosis and low
survival rates. The survival of patients with GC depends
mainly on the stage of the disease, with early GC having
a 5 year survival of 90-100% and advanced tumors a 5
year survival of 15-25%. The role of other prognostic
factors in these tumors is still under investigation. 28
gastric dysplasia, 45 Early GC and 98 Advanced Gastric
Cancers were evaluated for expression of the oncogenes
p53, c-ErbB2, c-myc and the EGFr in paraffin-embedded
material utilizing Avidin-Biotin immunohistochemistry
techniques. In 34 cases of GC microvessel density
(MVD) was determined in CD34 stained sections.
Statistical correlations with stage, histologic type,
differentiation degree, location, size, ploidy patterns and
overall survival were done. The Mantel-Cox test was
performed to evaluate which factors had an independent
prognostic value.
Both, tumor angiogenesis and p53 protein
expression were statistically associated (95% confidence
intervals) with overall survival in patients with GC. p53
protein expression was also correlated with cardial
location, nodal involvement and tumor stage. c-ErbB2
may recognize a group of highly aggressive well
differentiated adenocarcinomas with worse prognosis.
c-myc was also significantly enhanced in well
differentiated tumors. EGFr showed no significant
associations.
Mantel-Cox was performed to compare the
prognostic value of tumor stage, p53 protein expression
and tumor angiogenesis. Tumor angiogenesis was the
most important prognostic indicator to predict overall
survival in our series. p53 expression was not
independent and did not provide additional prognostic
information to tumor stage. Our study suggests that
angiogenesis as demonstrated by microvessel counts in
CD34 stained sections is a significantly important
Offprint requests to: Julian Sanz Ortega, MD, Departamento de
Anatomia Patolbgica, Hospital Universitario "San Carlos". Martin Lagos
s.n., Madrid 28040, Spain. Fax: 34-913303032, e-mail: jsanz@
hcsc.insalud.es
prognostic factor for predicting survival in gastric
cancer.
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