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Maternal undernutrition model of two generations of rats: Changes in the aged retina

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dc.contributor.authorLaurinaviciute, Guoda
dc.contributor.authorSimkunaite-Rizgeliene, R.
dc.contributor.authorZalgeviciene, V.
dc.contributor.authorCepuliene, R.
dc.contributor.authorJakimaviciene, E.M.
dc.contributor.authorGalgauskas, S.
dc.contributor.authorPetroska, D.
dc.contributor.authorBesusparis, J.
dc.contributor.authorTutkuviene, J.
dc.date.accessioned2023-03-30T06:16:28Z
dc.date.available2023-03-30T06:16:28Z
dc.date.issued2023
dc.description.abstractThe impact of maternal undernutrition on morphological changes of the retina was assessed in two generations of aged offspring. Wistar 18 rats (9 of each generation of 20-month-old female offspring; in total -27 eyes) were analyzed. The first generation offspring were born to mothers who: (a) were restricted to food only before pregnancy (pre-pregnancy); (b) whose food was restricted before and during pregnancy. The control group and all the offspring were fed normally. After enucleating the eyes, paraffin sections were stained with hematoxylin and eosin. The thickness of retina layers was measured. Cryosections were immunostained using glial fibrillary acidic protein, ionized calcium-binding adaptor molecule1, RNA-binding protein with multiple splicing for evaluation of macroglia, microglia and retinal ganglion cells by digital image analysis tools. Our data have shown atrophy of photoreceptor layer and degeneration of outer nuclear layer in all investigated groups, but less damage was found in the control group. Higher Müller cell activity and greater number of microglial cells was observed in the second generation offspring born from both restricted diet groups. Higher numbers of microglial and retinal ganglion cells were observed in the second generation in comparison to the first generation offspring. Malnutrition of the mother may be one of the possible causes of degeneration of the outer layers of the retina and activation of Müller cells in the second generation offspring. The effect of maternal nutritional restriction on the number of microglial and retinal ganglion cells is uncleares
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.citationHistology and Histopathology, Vol.38, nº4, (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-522
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/129743
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMacrogliaes
dc.subjectMaternal malnutritiones
dc.subjectMicrogliaes
dc.subjectPhotoreceptorses
dc.subjectRat’s retinaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMaternal undernutrition model of two generations of rats: Changes in the aged retinaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº4 (2023)