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Immunolocalization of antimicrobial and cytoskeletal components in the serous glands of human sinonasal mucosa

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dc.contributor.authorStoeckelhuber, Mechthild
dc.contributor.authorOlzowy, Bernhard
dc.contributor.authorIhler, Friedrich
dc.contributor.authorMatthias, Christoph
dc.contributor.authorScherer, Elias Q.
dc.contributor.authorBabaryka, Gregor
dc.contributor.authorLoeffelbein, Denys J.
dc.contributor.authorRohleder, Nils H.
dc.contributor.authorNieberler, Markus
dc.contributor.authorKesting, Marco R.
dc.date.accessioned2019-10-29T16:36:26Z
dc.date.available2019-10-29T16:36:26Z
dc.date.issued2014
dc.description.abstractSecretory cells in the seromucous glands of paranasal sinuses secrete antibacterial proteins for innate immune mucosal integrity. We studied the localization of antimicrobial and cytoskeletal components of the human seromucous glands and respiratory epithelium of the maxillary sinus and the ethmoidal cells by immunohistochemical methods. The presence of a variety of defense proteins such as lysozyme, lactoferrin, cathelicidin, and defensin-1, -2, -3 point to a crucial role in the immune defense for the respiratory tract. Cytoskeletal proteins such as actin, myosin 2, cytokeratin 7 and 19, α- and β-tubulin, investigated for the first time in glands of paranasal sinuses, showed a stronger expression at the apical and lateral cell membrane. The localization of the cytoskeletal proteins might point to their participation in exocrine secretory processes and stabilizing effects.es
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dc.format.extent10es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 10, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/76103
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHuman sinonasal muscosaes
dc.subjectSerous glandses
dc.subjectAntimicrobial Proteinses
dc.subjectCytoskeletones
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleImmunolocalization of antimicrobial and cytoskeletal components in the serous glands of human sinonasal mucosaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº10 (2014)