Publication: Glutamate-like immunoreactivity in axon terminals from the olfactory bulb to the piriform cortex
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Date
1998
Authors
Hennequet, L. ; Gondra, J. ; Sendino, J. ; Ortega, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A highly specific anti-glutamate monoclonal
antibody, mAb2D7, was used together with light and
electron microscopy to elucidate the role played by the
amino acid glutamate in the projection from the
olfactory bulb to the piriform cortex in the rat. By light
microscopy, glutamate-like immunoreactivity was
observed in neuronal cell bodies and in the neuropil of
the piriform cortex. Double labelling experiments which
involved injections of wheat germ agglutinin-horseradish
peroxidase into the olfactory bulb and a postembedding
immunogold method for electron microscopy
revealed anterogradely labelled terminals making
asymmetric synaptic contacts on dendrites in the
piriform cortex which contained high levels of glutamate
as assessed by quantification. These results further
support a role for glutamate as a neurotransmitter in the
efferent pathway of the rat olfactory bulb.
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