Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy Origins

García-Serna, Azahara M; Morales, Eva; Hernández Caselles, Trinidad; Martín-Orozco Santiago, María Elena

Publication:
Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy Origins

dc.contributor.author	García-Serna, Azahara M
dc.contributor.author	Morales, Eva
dc.contributor.author	Hernández Caselles, Trinidad
dc.contributor.author	Martín-Orozco Santiago, María Elena
dc.contributor.department	Bioquímica y Biología Molecular B e Inmunología
dc.date.accessioned	2024-01-28T14:04:20Z
dc.date.available	2024-01-28T14:04:20Z
dc.date.issued	2021-04-09
dc.description	©2020. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published, version of a Published Work that appeared in final form in International Journal of Environmental Research and Public Health. To access the final edited and published work see https://doi.org/10.3390/ijerph18083962	es
dc.description.abstract	It is suggested that programming of the immune system starts before birth and is shaped by environmental influences acting during critical windows of susceptibility for human development. Prenatal and perinatal exposure to physiological, biological, physical, or chemical factors can trigger permanent, irreversible changes to the developing immune system, which may be reflected in cord blood of neonates. The aim of this narrative review is to summarize the evidence on the role of the prenatal and perinatal environment, including season of birth, mode of delivery, exposure to common allergens, a farming environment, pet ownership, and exposure to tobacco smoking and pollutants, in shaping the immune cell populations and cytokines at birth in humans. We also discuss how reported disruptions in the immune system at birth might contribute to the development of asthma and related allergic manifestations later in life.	es
dc.format	application/pdf	es
dc.format.extent	24	es
dc.identifier.citation	International Journal of Environmental Research and Public Health 2021,18,3962
dc.identifier.doi	https://doi.org/10.3390/ijerph18083962
dc.identifier.issn	1660-4601
dc.identifier.issn	1661-7827
dc.identifier.uri	http://hdl.handle.net/10201/137856
dc.language	eng	es
dc.publisher	MDPI	es
dc.relation	This review received no external funding. A.M.G.S.was funded by a predoctoral Fellowship (FI17/00086) and E.M.was funded by Miguel Servet Fellowships (MS14/00046 and CPII19/00019) awarded by the Instituto de Salud CarlosIII (ISCIII), Spanish Ministry of Science, Innovation and Universities, and Fondos FEDER	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Early life	es
dc.subject	Environment	es
dc.subject	Immune system	es
dc.subject	Programming	es
dc.subject	Pregnancy	es
dc.title	Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy Origins	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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