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Elucidating the neuromeric organization of the Mongolian gerbil brain

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dc.contributor.authorLucero-Arteaga, F.
dc.contributor.authorLabegorra, S.
dc.contributor.authorAbrego-Álvarez, A.
dc.contributor.authorHeck, V.
dc.contributor.authorPortu, A. I.
dc.contributor.authorBoeris, M. A.
dc.contributor.authorAlonso Fuentes, Antonia
dc.contributor.authorRibeiro do Couto, Bruno
dc.contributor.authorGarcía-Cabezas, M. Á.
dc.contributor.authorTseng, K. Y.
dc.contributor.authorFerrán Bertone, José Luis
dc.contributor.departmentAnatomía Humana y Psicobiología
dc.contributor.otherFacultad de Medicina
dc.date.accessioned2026-01-13T12:34:54Z
dc.date.available2026-01-13T12:34:54Z
dc.date.copyright© 2025, The Author(s)
dc.date.issued2025-11-04
dc.description.abstractThe Mongolian Gerbil (Meriones unguiculatus) diverged from rats/mice around 45 million years ago and developed adaptations to extreme temperatures and water scarcity. Another feature of the Mongolian Gerbils is their social monogamy similar to that of prairie voles. These observations suggest that there are potential differences in the Mongolian Gerbil brain that are distinct from that of rats and mice. The goal of the present study is to establish the extent to which the neuromeric organization of the brain is conserved in the Mongolian Gerbil and to gain insights on how evolutionary expansion and diversification of brain regions occur across species. Our data shows that the multineuromeric origin of tyrosine hydroxylase-positive processes in the Mongolian Gerbil is similar to that in mice and rats, spanning from the diencephalon, midbrain, and the rostral hindbrain. There are also observable anatomical differences. However, most of the components characteristic of these neuromeres are identifiable in the Mongolian gerbil, closely mirroring those found in mice and rats. Together, these findings suggest that the conserved neuromeric organization likely stems from a restricted genetic toolset that began in the Muridae family 45 million years ago, and that a profound reorganization of the fundamental structural plan delineating the neuromeric segmentation is not required for the emergence of diverse functionality among species of phylogenetically related families. Future studies are needed to establish how the genetic programs within each neuromeric unit are influenced by environmental factors that ultimately impact the size of the neuromeric derivatives and their functional connectivity.
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dc.format.extent27
dc.identifier.citationBrain Structure and Function (2025) 230:171
dc.identifier.doihttps://doi.org/10.1007/s00429-025-03018-z
dc.identifier.eissn1863-2661
dc.identifier.issn1863-2653
dc.identifier.urihttp://hdl.handle.net/10201/186210
dc.languageeng
dc.publisherSpringer
dc.relationUniversities and European Regional Development Fund (FEDER; PGC2018-098229-B-100 to JLF), the Seneca Foundation-Science and Technology Agency of the Region of Murcia (21,903/PI/22 to JLF) and by NIH Grant R01-MH086507 (KYT) and Institutional funds from the University of Illinois Chicago - College of Medicine (KYT).
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00429-025-03018-z
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleElucidating the neuromeric organization of the Mongolian gerbil brain
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersión
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relation.isAuthorOfPublication.latestForDiscoverye6582236-1657-4fd1-8c98-d549ab609b91
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