Publication: Current concepts in ovarian epithelial tumorigenesis: correlation between morphological and molecular data
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Date
2006
Authors
Scott, Mike ; McCluggage, W.G
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Ovarian carcinoma is the most lethal
gynaecological malignancy, most tumours being
advanced at presentation. However, little is known about
precursor lesions and the cell of origin of epithelial
ovarian malignancy. In this review, the proposed cell of
origin is discussed as well as recent molecular data
relating to ovarian cancers of different morphological
types. It is stressed that ovarian carcinoma is a
heterogeneous group of neoplasms with several different
morphological types, each with their own underlying
molecular genetic events. Recent data suggest that
mucinous ovarian cancers and a small subset of serous
cancers (low grade ovarian serous carcinoma) develop
through a well-defined adenoma-carcinoma sequence
while the much more common high grade ovarian serous
carcinoma develops de novo from the ovarian surface
epithelium or the epithelium of cortical inclusion cysts.
The realisation that various morphological types of
epithelial ovarian cancer are associated with different
molecular genetic events is a major advance in the study
of ovarian cancer. It can be anticipated that this will lead
to the development of specific therapeutic agents of
value against a specific tumour type.
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