Publication:
KIR gene mismatching and KIR/C ligands in liver transplantation: consequences for short-term liver allograft injury

Simple item page
dc.contributor.authorLópez Álvarez, María R.
dc.contributor.authorCampillo, José A.
dc.contributor.authorMoya Quiles, María Rosa
dc.contributor.authorBolarín, José Miguel
dc.contributor.authorPeña, Jesús de la
dc.contributor.authorSalgado, Gema
dc.contributor.authorGarcía Alonso, Ana M.
dc.contributor.authorMuro, Manuel
dc.contributor.authorMiras, Manuel
dc.contributor.authorAlonso, Clara
dc.contributor.authorÁlvarez López, María Rocio
dc.contributor.authorMinguela, Alfredo
dc.contributor.authorGimeno Arias, Lourdes
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-12T08:06:36Z
dc.date.available2024-07-12T08:06:36Z
dc.date.issued2013-04-27
dc.description© 2013 Lippincott Williams & Wilkins. This document is the Published version of a Published Work that appeared in final form in Transplantation. To access the final edited and published work see https://doi.org/10.1097/TP.0b013e318286486c
dc.description.abstractBackground. Killer immunoglobulin-like receptors (KIRs) bind human leukocyte antigen (HLA) class-I (HLA-I) ligands and regulate functions of natural killer cells and subsets of T cells. KIR/HLA-I interactions allow predicting natural killer cell alloreactivity in hematopoietic stem cell transplantation and in HLA-compatible kidney transplants, but its meaning in liver transplantation remains controversial. Methods. KIR and HLA genotypes were studied in 402 liver transplants, using sequence-specific oligonucleotides and primer methods. Recipients and donor KIRs, HLA-C genotypes, KIR gene mismatches (MMs) between recipient-donor pairs, and KIR/HLA-ligand combinations were analyzed in overall transplantations, in the acute rejection (AR; n=110) and non-AR (n=292) groups. Results. KIR gene MMs between recipients and donors, mainly in activating KIRs, and KIR2DL3 and KIR2DS1 of recipients in the presence of donor C2 ligands, significantly enhanced early AR rate (P<0.05), with KIR2DL3+ and KIR2DS1+ exhibiting a synergic effect in dependence of the donor C2 ligand number (χ2=7.662, P=0.022). KIR2DL3, KIR2DS1, and also KIR2DS4+ significantly influenced short-term graft survival, with a benefit for transplantations combining KIR2DL3+ recipients and donors having C1 ligands (log rank, P<0.019 at 1 year; hazards ratio [HR], 0.321; 95% confidence interval [CI], 0.107–0.962; P=0.042), whereas KIR2DS1+ and KIR2DS4+ recipients combined with donors lacking C1 ligands (C2/C2) exhibited a worse graft survival (log rank, P=0.035 at 6 months; HR, 7.713; 95% CI, 2.156–27.369; P=0.002 for KIR2DS1+; and log rank, P=0.006 at 1 year; HR, 3.794; 95% CI, 1.267–11.365; P=0.017 for KIR2DS4). Conclusions. This study shows that KIR gene-gene MMs increase AR and that KIRs/C ligands associated to AR and KIR2DS4+/C ligands also influence short-term graft survival.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationTransplantation Journal 2013 95(8): 1037-1044
dc.identifier.doihttps://doi.org/10.1097/TP.0b013e318286486c
dc.identifier.issnPrint: 0041-1337
dc.identifier.issnElectronic: 1534-6080
dc.identifier.urihttp://hdl.handle.net/10201/143024
dc.languageenges
dc.publisherLippincott, Williams & Wilkins
dc.relationThe authors thank the CIBERehd scientific program, funded by the Instituto de Salud Carlos III.es
dc.relation.publisherversionhttps://journals.lww.com/transplantjournal/Fulltext/2013/04270/KIR_Gene_Mismatching_and_KIR_C_Ligands_in_Liver.9.aspx
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectKIRes
dc.subjectHLA ligandses
dc.subjectLiver transplantationes
dc.subjectAcute rejectiones
dc.subjectShort-term graft survivales
dc.titleKIR gene mismatching and KIR/C ligands in liver transplantation: consequences for short-term liver allograft injuryes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationa0170301-b64f-46f8-810a-ff18c9bf0a5f
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoverya0170301-b64f-46f8-810a-ff18c9bf0a5f
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
kir_gene_mismatching_and_kir_c_ligands_in_liver.9.pdf
Size:
396.32 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos