Publication: The role of the epidermal growth factor-like protein dlk in cell differentiation
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Date
2000
Authors
Laborda, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This review focuses on the current
knowledge about the function of the EGF-like homeotic
protein dlk. dlk is a transmembrane protein that
possesses six Epidermal Growth Factor-like sequences at
the extracellular domain, a single transmembrane
domain and a short intracellular tail. Because of its
overall structure and amino acid homology, dlk belongs
to the EGF-like homeotic protein family. This family
includes proteins such as the Notch receptor and its
homologues, as well as Notch ligands, such as Delta,
Serrate, and their mammalian homologues DIl1, D112
and D113 and Jagged 1 and Jagged 2. (For a recent
review see Fleming, 1998). dlk is highly expressed by
preadipose cell lines, and neuroendocrine tumors, such
as pheochromocytomas and neuroblastomas. dlk has
been involved in several differentiation processes, such
as adipogenesis, hematopoiesis and B cell lymphopoiesis,
and neuroendocrine differentiation, including the
differentiation of pancreas and the adrenal gland. The
extracellular region of dlk can be released by action of
an unknown protease and this soluble dlk variant
accumulates in the amniotic fluid and is able to inhibit
adipocyte differentiation in vitro. Recent evidence
indicates, however, that membrane-associated dlk
variants play a positive role in the differentiation
process. These findings suggest that dlk plays an
important role in differentiation and tumorigenesis of
several cellular types.
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