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Signaling pathways governing osteoblast proliferation, differentiation and function

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dc.contributor.authorFung Ling Chau, Jennyes
dc.contributor.authorFook Leong, Waies
dc.contributor.authorLi, Baojie
dc.date.accessioned2014-01-09T10:39:08Z
dc.date.available2014-01-09T10:39:08Z
dc.date.issued2009
dc.description.abstractOsteoblasts are bone forming cells that are responsible for bone growth and remodeling. They are derived from bone marrow mesenchymal stem cells through a series of processes including commitment, osteoprogenitor expansion, terminal differentiation and cell death. Osteoblastogenesis and bone formation are regulated by hormones, growth factors, cytokines, mechanical loading and aging. Osteoblasts can sense these external cues, transduce the signals through various signaling pathways and regulate the expression of specific genes, to determine the cell fate. In this review, we aim to update our current understanding of the signaling pathways that control different steps of osteoblast homeostasis, with special focus on how signaling events control cell fate through regulating gene expression.es
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/37561
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectOsteoblastes
dc.subject.other577 - Bioquímica. Biología molecular. Biofísicaes
dc.titleSignaling pathways governing osteoblast proliferation, differentiation and functiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24,nº12 (2009)