Publication: A comparison of cyclosporine A and cyclosporine
G in a rabbit heterotopic cardiac transplant model:
graft outcome and histological findings
Authors
Fryer, J.P. ; Pascoe, E.A. ; Yatscoff, R.W. ; Thliveris, J.A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cervical heterotopic heart transplants
were performed on 20 male New Zealand white
rabbits comprising 4 treatment groups. Animals in each
group were injected daily via the marginal ear vein
and received one of the following regimes: Cyclosporine
A, 10 mglkglday; Cyclosporine G, 15 mglkglday;
cremophor-El, 3mllday; or normal saline. Measurement
of 24 hour trough blood concentrations revealed
no significant differences between the average
concentrations of Cyclosporine A and Cyclosporine
G. Animals were examined daily and the cervical
allografts assessed by palpation for viabilitylrejection.
The duration of the study ended for each animal
when the graft stopped beating at which time the animals
was euthanized and the transplanted heart and
native kidneys harvested and processed for light
microscopy evaluation of rejection and drug toxicity,
respectively.
Graft survival in the Cyclosporine A group
significantly surpassed that seen in the Cyclosporine G
group as well as the control groups, whereas in animals
treated with Cyclosporine G, graft survival was not
different from controls. In the native kidney, there were
no differences in glomerular tuft area or volume density
amongst drug-treated or control animals. In contrast,
tubule atrophy and interstitial fibrosis were markedly
greater in Cyclosporine A-treated vs Cyclosporine Gtreated
animals.
The results of this study indicate that, whereas
Cyclosporine G is less nephrotoxic than Cyclosporine A,
given equivalent blood concentrations Cyclosporine A
delays rejection of a cardiac allograft significantly
longer than Cyclosporine G in this animal species.
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