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Current epidemiology and outcome of infective endocarditis: A multicenter, prospective, cohort study

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dc.contributor.authorMuñoz, Patricia
dc.contributor.authorKestler, Martha
dc.contributor.authorAlarcon, Arístides de
dc.contributor.authorMiro, José María
dc.contributor.authorBermejo, Javier
dc.contributor.authorRodríguez-Abella, Hugo
dc.contributor.authorFariñas, Maria Carmen
dc.contributor.authorCobo Belaustegui, Manuel
dc.contributor.authorMestres, Carlos
dc.contributor.authorLlinares, Pedro
dc.contributor.authorGoenaga, Miguel
dc.contributor.authorNavas, Enrique
dc.contributor.authorOteo, José Antonio
dc.contributor.authorTarabini, Paola
dc.contributor.authorBouza, Emilio
dc.contributor.authorGarcía-Vázquez, Elisa
dc.contributor.authorGrupo de Apoyo al Manejo de la Endocarditis Infecciosa en España (GAMES)
dc.contributor.departmentMedicina
dc.date.accessioned2024-06-26T08:29:29Z
dc.date.available2024-06-26T08:29:29Z
dc.date.issued2015-09-21
dc.description©2015 Wolters Kluwer Health, Inc.. This manuscript version is made available under the CC BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published, version of a Published Work that appeared in final form in Medicine. To access the final edited and published work see https://doi.org/10.1097/MD.0000000000001816es
dc.description.abstractThe aim of the study was to describe the epidemiologic and clinical characteristics and identify the risk factors of short-term and 1-year mortality in a recent cohort of patients with infective endocarditis (IE). From January 2008, multidisciplinary teams have prospectively collected all consecutive cases of IE, diagnosed according to the Duke criteria, in 25 Spanish hospitals. Overall, 1804 patients were diagnosed. The median age was 69 years (interquartile range, 55–77), 68.0% were men, and 37.1% of the cases were nosocomial or health care-related IE. Gram-positive microorganisms accounted for 79.3% of the episodes, followed by Gram-negative (5.2%), fungi (2.4%), anaerobes (0.9%), polymicrobial infections (1.9%), and unknown etiology (9.1%). Heart surgery was performed in 44.2%, and in-hospital mortality was 28.8%. Risk factors for in-hospital mortality were age, previous heart surgery, cerebrovascular disease, atrial fibrillation, Staphylococcus or Candida etiology, intracardiac complications, heart failure, and septic shock. The 1-year independent risk factors for mortality were age (odds ratio [OR], 1.02), neoplasia (OR, 2.46), renal insufficiency (OR, 1.59), and heart failure (OR, 4.42). Surgery was an independent protective factor for 1-year mortality (OR, 0.44). IE remains a severe disease with a high rate of in-hospital (28.9%) and 1-year mortality (11.2%). Surgery was the only intervention that significantly reduced 1-year mortality.es
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dc.format.extent8es
dc.identifier.citationMedicine 94(43):e1816
dc.identifier.doihttps://doi.org/10.1097/MD.0000000000001816
dc.identifier.issnPrint: 0025-7974
dc.identifier.issnElectronic: 1536-5964
dc.identifier.urihttp://hdl.handle.net/10201/142683
dc.languageenges
dc.publisherLippincott, Williams & Wilkinses
dc.relationThis study was partially financed by the CIBER de Enfermedades Respiratorias (CIBERES) from the ISCIII (CB06/06/0058) and by Fundación BBVA-Fundacio´n Carolina (research fellowship of Maricela Valerio).es
dc.relation.publisherversionhttps://journals.lww.com/md-journal/fulltext/2015/10270/current_epidemiology_and_outcome_of_infective.37.aspxes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleCurrent epidemiology and outcome of infective endocarditis: A multicenter, prospective, cohort studyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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