Publication: Receptor-binding cancer antigen expressed on SiSo cells (RCAS1), a novel biomarker in the diagnosis and prognosis of human neoplasia
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Date
2009
Authors
Giaginis, constantinos ; Giagini, Athina ; Theocharis, Stamatios E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The receptor-binding cancer antigen
expressed on SiSo cells (RCAS1) is a novel tumorassociated
antigen that induces cell-cycle arrest and/or
apoptosis in RCAS1 receptor-bearing human cells.
Current evidence has revealed enhanced RCAS1
expression in the tumor malignant stage of several
organs, which may play a crucial role in tumor
progression by enabling cancer cells to evade immune
surveillance. In the last few years, tissue RCAS1 protein
expression and circulating levels in biofluids have
further been the focus of extensive research as a
diagnostic and prognostic marker in several human
malignancies. The present article aimed to review the
available data so far concerning the clinical significance
of RCAS1 in human neoplasia. Reviewing of English
literature revealed that tissue RCAS1 expression was
associated with important clinicopathological parameters
for patients' management and prognosis, being
considered as an informative biomarker in several types
of human malignancy. In addition, the current evidence
supported a crucial role for RCAS1 in tumor immune
escape, which renders this receptor a promising target
for future (gene) therapeutic approaches. However, the clinical application of circulating RCAS1 concentrations
in biofluids as a marker in the management and
prognosis of tumor malignancies needs to be further
explored, since the data so far are still extremely limited.
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