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Roles of TGF-beta 1 signaling in the development of osteoarthritis

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dc.contributor.authorFang, Jie
dc.contributor.authorXu, Lin
dc.contributor.authorLi, Yefu
dc.contributor.authorZhao, Zhihe
dc.date.accessioned2021-11-12T11:55:56Z
dc.date.available2021-11-12T11:55:56Z
dc.date.issued2016
dc.description.abstractOsteoarthritis (OA) is a degenerative joint disorder characterized by the destruction of articular cartilage, subchondral bone and other joint tissues. Although multiple growth factors and cytokines have been shown to be involved in articular cartilage degeneration and subchondral bone destruction, which eventually leads to OA, the molecular mechanisms underlying the pathogenesis of OA are largely unknown. The canonical transforming growth factor beta 1 (TGFβ1) signaling functions as one of the key factors in cartilage and bone formation, remodeling, and maintenance. However, the effects of TGF-β1 signaling on the development of OA are unclear. Numerous studies provide evidence that TGF-β1 is required for the formation of articular cartilage at early stages of joint development. In contrast, other investigations indicate that TGF-β1 may, in fact, be a factor in joint destruction. Therefore, we, in this review article, discuss the “conflicting” roles of TGF-β1 signaling in the development of OA.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.citationHistology and Histopathology, Vol.31, nº11, (2016)
dc.identifier.doiDOI: 10.14670/HH-11-779
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/113984
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectTGF-β1es
dc.subjectArticular cartilagees
dc.subjectKnee jointes
dc.subjectOsteoarthritises
dc.subjectMouse modeles
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleRoles of TGF-beta 1 signaling in the development of osteoarthritises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31,nº 11 (2016)