Publication: Beta-catenin expression pattern in small cell lung cancer: correlation with clinical and evolutive features
Authors
Rodríguez-Salas, N. ; Palacios, J. ; Castro, J.de ; Moreno, G. ; González-Barón, M. ; Gamallo, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
B-catenin expression in small cell lung
carcinomas (SCLC) was investigated by immunohistochemical
method using antibodies against B-catenin. 50
pre-treatment biopsies were examined and the
relationship between B-catenin expression and the
patients' relevant clinical characteristics, response to
chemotherapy, time to relapse or progression, and
overall survival, were analyzed. 0-catenin expression
exhibited different intensity within each sample,
predominantly localized in the cytoplasm, and no sample
showed nuclear expression. There was cytoplasmic
hyperexpression in 14 cases, hypoexpression in 15 cases,
and normal expression in 21 cases. We did not find any
association between B-catenin expression and clinical
data. Our results show, however, correlation between Bcatenin
cytoplasmic hyperexpression with a shorter time
to progression (p=0.0437) as well as with a shorter
overall survival @=0.0253). B-catenin hyperexpression
could have prognostic significance in SCLC.
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