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PD-L1 positive lympho-epithelial lesions in inflammatory prostate

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dc.contributor.authorDikov, Dorian
dc.contributor.authorKoleva, Maria
dc.contributor.authorSimitchiev, Kiril
dc.contributor.authorBaltov, Marin
dc.contributor.authorSarafian, Victoria
dc.date.accessioned2023-02-27T12:52:30Z
dc.date.available2023-02-27T12:52:30Z
dc.date.issued2022
dc.description.abstractObjectives. Ductal epithelial changes (lympho-epithelial lesions-LEL) in prostatic chronic inflammation (CI) are not well studied so far. Aim. To investigate LEL immediately adjacent to prostatic CI. Methods. We studied LEL in 144 prostatic surgical and autopsy specimens in various types of prostatic CI: NIH-category IV prostatitis (histologic prostatitis-HP), nonspecific granulomatous prostatitis (NSGP), and the reactive lymphoid infiltrates in the vicinity of benign prostatic hyperplasia (BPH) and prostate adenocarcinoma (PCa). CI is scored as low and high grade (LG, HG) according to the severity of inflammation. Results. LEL was identified in all types of prostatic specimens and in all types of prostatic CI: in 70.9% of patients with HP; in 100% of cases with NSGP; in 68.7% and in 80% adjacent to BPH and PCa respectively. Statistical analysis showed a significant correlation of the presence of LEL with HG CI (p<0.001). LEL showed strong membranous PD-L1 expression. Conclusions. The study presents the first attempt to examine LEL in inflammatory human prostate. PD-L1 positive LEL have no diagnostic organ specificity, although they are a constant histological finding in HG prostatic CI. LEL, inducible after birth by CI, are an integral part of prostate-associated lymphoid tissue (PALT) and of the inflammatory prostatic microenvironmentes
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dc.identifier.citationHistology and Histopathology Vol. 37, nº8 (2022)
dc.identifier.doihttps://doi.org/10.14670/HH-18-479
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/128824
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectProstatitises
dc.subjectLympho epithelial lesionses
dc.subjectInflammationes
dc.subjectPD-L1es
dc.subjectPALTes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titlePD-L1 positive lympho-epithelial lesions in inflammatory prostatees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.37, nº8 (2022)