Publication: The histopathology of tissue lead retention
Authors
Greenberg, Stephen R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
An experimental murine model of chronic
lead retention is established. This model excludes joint
communication and synovial fluid solubility of lead ions
recognized in human gunshot injury. Degenerative
changes in the visceral organs and bone appear in these
mice 30 days after implantation of lead spheres in the
subcutaneous tissues of the posterior body wall.
Degeneration, necrosis and interstitial fibrosis of the
lung, kidney and remodeling of femoral bone are noted
during the course of the experiment (120 days). It is
concluded that the systemic diffusion of lead ions from a
central focus is related to the development of an
absorptive circulatory mechanism around the retained
peripheral lead mass.
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Citation
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