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Myxoid pleomorphic liposarcoma

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dc.contributor.authorFadaei, Sharareh
dc.contributor.authorCordier, Fleur
dc.contributor.authorFerdinande, Liesbeth
dc.contributor.authorDorpe, Jo Van
dc.contributor.authorCreytens, David
dc.date.accessioned2024-09-05T08:15:59Z
dc.date.available2024-09-05T08:15:59Z
dc.date.issued2024
dc.description.abstractMyxoid pleomorphic liposarcoma (MPL) is an extremely rare adipocytic tumor, recently recognized as a distinct entity in the 5th edition of the World Health Organization (WHO) Classification of Soft Tissue and Bone Tumors. Predominantly found in the mediastinum of young women, MPLs exhibit a combination of histological features characteristic of myxoid liposarcoma and pleomorphic (lipo)sarcoma. Their unique molecular features distinguish MPLs from other liposarcomas. Unlike myxoid liposarcomas and well-differentiated/dedifferentiated liposarcomas, MPLs lack specific FUS/EWSR1::DDIT3 gene fusions and MDM2/CDK4 gene amplifications, respectively. MPLs are associated with complex karyotypes, further highlighting their distinct genetic profile. They demonstrate aggressive growth patterns, high recurrence rates, and a high tendency to metastasize. These factors contribute to a poor prognosis, with a median survival of approximately 22.6 months. The aim of this review article is to provide a comprehensive summary of previously documented case reports and studies related to MPLs. By shedding light on the intricate details of MPLs, researchers and clinicians can gain valuable insights that may pave the way for improvements in diagnosis, treatment, and patient outcomes in the future.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology Vol. 39, nº9 (2024)
dc.identifier.doihttps://doi.org/10.14670/HH-18-724
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/143599
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMyxoid pleomorphic liposarcoma (MPL)es
dc.subjectPleomorphic liposarcoma (PL)es
dc.subjectMyxoid liposarcoma (ML)es
dc.subjectDedifferentiated liposarcoma (DDLP)es
dc.subjectAtypical spindle cell/pleomorphic lipomatous tumor (ASPLT)es
dc.subjectRetinoblastoma 1 (RB1)es
dc.subjectMDM2es
dc.subjectCDK4es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMyxoid pleomorphic liposarcomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.39, nº9 (2024)