Publication:
The urokinase-system - role of cell proliferation and apoptosis

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The urokinase-system - role of cell proliferation and apoptosis.pdf(406.5 KB)
Date
2008
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Authors
Hildenbrand, Ralf ; Gandhari, Mukesh ; Stroebel, Philipp ; Marx, Alexander ; Allgayer, Heike ; Arens, Norbert
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The serine protease urokinase-type plasminogen activator (uPA) and its receptor (uPAR) are involved in the control of extracellular matrix turnover, cell migration, invasion and cell signalling leading to a variety of different responses, under both physiological and pathological conditions. The urokinase receptor, binding to the growth factor-like domain of uPA, directs membrane-associated extracellular proteolysis and signals through transmembrane proteins, thus regulating tissue regeneration, angiogenesis, cancer growth and metastasis. Since these physiological and pathophysiological processes of the uPA-system are known, less informations concerning uPA-induced cell proliferation and anti-apoptotic effects of the uPAsystem are available. Recent studies show a close relationship of the uPA-system and cell proliferation/ apoptosis. uPA is responsible for the activation and release of different growth factors and modulates the cell proliferation/apoptosis ratio through the dynamic control of cell-matrix interactions. This article focuses on the important role of the uPA/uPAR-system for cell proliferation and apoptosis.
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Urokinase , Cell proliferation
Citation
URI
http://hdl.handle.net/10201/29792
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Histology and histopathology Vol.23, nº2 (2008)
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