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Alloxan-induced hyperglycemia causes rapid-onset and progressive dental caries and periodontitis in F344 rats

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dc.contributor.authorNakahara, Yutaka
dc.contributor.authorSano, Tomoya
dc.contributor.authorKodama, Yasushi
dc.contributor.authorOzaki, Kiyokazu
dc.contributor.authorMatsuura, Tetsuro
dc.date.accessioned2017-11-08T15:29:44Z
dc.date.available2017-11-08T15:29:44Z
dc.date.issued2012
dc.description.abstractWe have previously shown that diabetes increases dental caries, and periodontitis might be a secondary change resulting from dental caries in spontaneous diabetic rodent models. However, the lesions in these models were slow to manifest, and the intensity and frequency were mild and varied among individuals. The goal of this study was to confirm the reproducibility of caries development in chemically induced diabetic rats and investigate whether alloxan, which induces immediate and severe hyperglycemia in experimental animals, increases the lesions. Female F344 rats were examined 13 and 26 weeks after dosing of alloxan. Alloxan injection induced severe hyperglycemia in two-thirds of the rats. Progressive molar caries and periodontitis were already induced in all diabetic rats 13 weeks after dosing of alloxan, although the lesions were not observed in nondiabetic rats. Histopathologically, dental caries initially developed in the crown, then spread into the dental root, entered the periodontal connective tissue via the apical foramen, and progressed to periodontitis. In conclusion, alloxan-induced severe hyperglycemia is capable of causing rapid-onset and progressive dental caries and periodontitis in rats.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 10 (2012)
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/54456
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectDiabeteses
dc.subjectDental carieses
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biologíaes
dc.titleAlloxan-induced hyperglycemia causes rapid-onset and progressive dental caries and periodontitis in F344 ratses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº10 (2012)