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Prosomeric hypothalamic distribution of tyrosine hydroxylase positive cells in adolescent rats

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dc.contributor.authorBilbao, María G.
dc.contributor.authorGarrigos, Daniel
dc.contributor.authorMartínez Morga, Marta
dc.contributor.authorToval, Ángel
dc.contributor.authorKutsenko Shchegolska, Yevheniy
dc.contributor.authorBautista, Rosario
dc.contributor.authorBarreda, Alberto
dc.contributor.authorRibeiro do Couto, Bruno
dc.contributor.authorPuelles López, Luis
dc.contributor.authorFerrán Bertone, José Luis
dc.contributor.departmentAnatomía Humana y Psicobiología
dc.date.accessioned2026-01-13T12:47:00Z
dc.date.available2026-01-13T12:47:00Z
dc.date.copyright© 2022, los autores
dc.date.issued2022-05-06
dc.description.abstractMost of the studies on neurochemical mapping, connectivity, and physiology in the hypothalamic region were carried out in rats and under the columnar morphologic paradigm. According to the columnar model, the entire hypothalamic region lies ventrally within the diencephalon, which includes preoptic, anterior, tuberal, and mamillary anteroposterior regions, and sometimes identifying dorsal, intermediate, and ventral hypothalamic partitions. This model is weak in providing little or no experimentally corroborated causal explanation of such subdivisions. In contrast, the modern prosomeric model uses different axial assumptions based on the parallel courses of the brain floor, alar-basal boundary, and brain roof (all causally explained). This model also postulates that the hypothalamus and telencephalon jointly form the secondary prosencephalon, separately from and rostral to the diencephalon proper. The hypothalamus is divided into two neuromeric (transverse) parts called peduncular and terminal hypothalamus (PHy and THy). The classic anteroposterior (AP) divisions of the columnar hypothalamus are rather seen as dorsoventral subdivisions of the hypothalamic alar and basal plates. In this study, we offered a prosomeric immunohistochemical mapping in the rat of hypothalamic cells expressing tyrosine hydroxylase (TH), which is the enzyme that catalyzes the conversion of L-tyrosine to levodopa (L-DOPA) and a precursor of dopamine. This mapping was also combined with markers for diverse hypothalamic nuclei [agouti-related peptide (Agrp), arginine vasopressin (Avp), cocaine and amphetamine-regulated transcript (Cart), corticotropin releasing Hormone (Crh), melanin concentrating hormone (Mch), neuropeptide Y (Npy), oxytocin/neurophysin I (Oxt), proopiomelanocortin (Pomc), somatostatin (Sst), tyrosine hidroxilase (Th), and thyrotropin releasing hormone (Trh)]. TH-positive cells are particularly abundant within the periventricular stratum of the paraventricular and subparaventricular alar domains. In the tuberal region, most labeled cells are found in the acroterminal arcuate nucleus and in the terminal periventricular stratum. The dorsal retrotuberal region (PHy) contains the A13 cell group of TH-positive cells. In addition, some TH cells appear in the perimamillary and retromamillary regions. The prosomeric model proved useful for determining the precise location of TH-positive cells relative to possible origins of morphogenetic signals, thus aiding potential causal explanation of position-related specification of this hypothalamic cell type.
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dc.format.extent36
dc.identifier.citationFront. Neuroanat. 16:868345
dc.identifier.doihttps://doi.org/10.3389/fnana.2022.868345
dc.identifier.eissn1662-5129
dc.identifier.urihttp://hdl.handle.net/10201/186369
dc.languageeng
dc.publisherFrontiers Media
dc.relationThis study was funded by the Spanish Ministry of Science, Innovation, and Universities (MCIU), State Research Agency (AEI), and European Regional Development Fund (FEDER); PGC2018-098229-B-100 to JF and by Séneca Foundation (19904/GERM/15).
dc.relation.publisherversionhttps://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2022.868345/full
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPOMC
dc.subjectHypothalamic dopamine
dc.subjectTerminal hypothalamus
dc.subjectPeduncular hypothalamus
dc.subjectAcroterminal hypothalamus
dc.subjectArcuate nucleus
dc.subjectParaventricular nucleus
dc.subjectA13 group
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.subject.otherFacultad de Medicina
dc.titleProsomeric hypothalamic distribution of tyrosine hydroxylase positive cells in adolescent rats
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersión
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