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Gamma-aminobutyric acid GABA and cell proliferation, focus on cancer cells

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dc.contributor.authorWatanabe, M.es
dc.contributor.authorMaemura, K.es
dc.contributor.authorOki, K.
dc.contributor.authorShiraishi, N.
dc.contributor.authorShibayama, Y.
dc.contributor.authorKatsu, K.
dc.date.accessioned2011-06-30T12:01:33Z
dc.date.available2011-06-30T12:01:33Z
dc.date.issued2006
dc.description.abstractIn addition to its role in the adult mammalian nervous system as an inhibitory neurotransmitter, g-aminobutyric acid (GABA) is involved in the proliferation, differentiation, and migration of several kinds of cells including cancer cells. GABA is synthesized predominantly from glutamate by glutamate decarboxylase and exerts its effects via ionotropic GABAA receptors and/or metabotropic GABAB receptors. In this review, the current state of knowledge regarding the role of the GABAergic system in peripheral nonneuronal cell proliferation is described, and recent advances in elucidation of the mechanisms leading to cell proliferation are discussed.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22575
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectProliferationes
dc.subjectCanceres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleGamma-aminobutyric acid GABA and cell proliferation, focus on cancer cellses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.21, nº10 (2006)