Clinical applications of detecting dysfunctional p53 tumor suppressor protein

Publication:
Clinical applications of detecting dysfunctional p53 tumor suppressor protein

dc.contributor.author	Baas, I.O.	es
dc.contributor.author	Hruban, R.H.	es
dc.contributor.author	Offerhaus, G.J.A.
dc.date.accessioned	2011-02-22T11:07:43Z
dc.date.available	2011-02-22T11:07:43Z
dc.date.issued	1999
dc.description.abstract	The p53 gene encodes for a protein, p53, which plays a critical role in controlling the cell cycle, in DNA repair and in programed cell death (apoptosis). p53 is one of the most frequently mutated genes in human neoplasms and a variety of techniques have been developed to detect these mutations. These range from advanced molecular-genetic analyses to immunohistochemical staining for the p53 protein. This review will summarize our current understanding of the function of p53 as well as current methods to detect dysfunctional p53 and the clinical value of such analyses.	es
dc.format	application/pdf	es
dc.format.extent	6	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/19146
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Cell cycle	es
dc.subject	Neoplasia	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología	es
dc.title	Clinical applications of detecting dysfunctional p53 tumor suppressor protein	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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