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HtrA1 loss is related to aggressive behavior parameters in sentinel node positive breast cancer

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dc.contributor.authorFranco, Renato
dc.contributor.authorCollina, Francesca
dc.contributor.authorDi Bonito, Maurizio
dc.contributor.authorBotti, Gerardo
dc.contributor.authorMontanaro, Donatella
dc.contributor.authorDi Maio, Luigi
dc.contributor.authorVincenz, Bruno
dc.contributor.authorLandi, Gabriella
dc.contributor.authorD’Aiuto, Massimiliano
dc.contributor.authorCaraglia, Michele
dc.contributor.authorBaldi, Alfonso
dc.date.accessioned2020-09-18T09:34:21Z
dc.date.available2020-09-18T09:34:21Z
dc.date.issued2015
dc.description.abstractAim: HtrA1, a member of the High Temperature Requirement Factor A family of oxidative stress-response proteases seems to play a role as a tumor suppressor, being down-regulated in a series of human cancers during their progression. Particularly, low HtrA1 mRNA levels have been observed in breast cancer patients with more aggressive clinical features. These have been shown to relate to a longer disease free and overall survival, with more pronounced effects in axillary nodes positive patients. Subjects and Methods: We have analyzed for immunohistochemical HtrA1 expression a series of 66 sentinel node positive breast cancers through Tissue Micro Array technology. Results: HtrA1 was absent to low in 29 cases, medium in 19 cases and high in 18 cases. Our data revealed a positive significant relation between HtrA1 expression level and estrogen (p=0,002) and progestinic receptor expression (p=0.003) and a negative correlation with histological grading (p=0.028), proliferation index (p=0.05), common BC histotypes (p=0.040), luminal A and B subtypes (p=0.001), metastasis development (p<0.0001) and local relapse (p<0.0001). Finally, no correlation was recorded between HtrA1 expression level and breast cancer histology type and metastasis to non sentinel nodes. Interestingly HtrA1 loss in SLN metastasis was able to predict positive non sentinel nodes (p=0.001). Conclusions: Low HtrA1 expression is significantly related to breast cancer poor prognosis parameters, and HtrA1 loss in sentinel nodes is related to metastasis of non sentinel nodes, offering a further marker useful for BC prognostic stratification.es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology, vol. 30, nº 6, (2015)
dc.identifier.doi10.14670/HH-30.707
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/96126
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBreast Canceres
dc.subjectHTRA1es
dc.subjectTumor suppressores
dc.subjectTissue MicroArrayes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleHtrA1 loss is related to aggressive behavior parameters in sentinel node positive breast canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº6 (2015)