Publication: Blastic OKT6-positive proliferation preceding malignant histiocytosis
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Date
1986
Authors
Bonetti, F. ; Chilosi, M. ; Menestrina, F. ; Lestani, M. ; Scarpa, A. ; Todeschini, G. ; Pizzolo, G. ; Fioredonati, L
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A 45-year old male presented latero-cervical
lymphoadenopathy. Biopsy revealed a malignant
proliferation of immature "lymphoid" cells bearing T6
antigen and HLA-DR but negative for other lymphoid
markers, suggesting a phenotype similar to Langerhans
cells. The patient did not receive any therapy and six months
later developed a histologically typical malignant
histiocytosis, involving spleen and liver. Other reported
cases of lymphoid malignancies (two bearing the 7'6 antigen
on blast cells) preceding malignant histiocytosis were found
and compared with ours. Most of these cases were
characterized by the pediatric age of the patients and were
presented as acute leukemias exhibiting, in at least some
of them, reliable T-cell markers.
Our case appears to represent, on the other hand, a
blastic proliferation of precursors of both histiocytes and
Langerhans dendritic cells which eventually progressed to
malignant histiocytosis. The relevance of this observation
in the debate on the origin of Langerhans cells and the
relationships existing between macrophages and dendritic
cells is discussed.
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