Publication:
Current therapies for hypertrophic cardiomyopathy: a systematic review and meta-analysis of the literature

Simple item page
dc.contributor.authorBayonas Ruiz, Adrián
dc.contributor.authorMuñoz Franco, Francisca María
dc.contributor.authorSabater Molina, María
dc.contributor.authorOliva Sandoval, María José
dc.contributor.authorGimeno Blanes, Juan Ramón
dc.contributor.authorBonacasa Fernández, Bárbara
dc.contributor.departmentFisiología
dc.date.accessioned2026-02-06T13:02:43Z
dc.date.available2026-02-06T13:02:43Z
dc.date.copyright© 2022 The Authors
dc.date.issued2022-10-01
dc.description.abstractAims The aim of this study was to synthesize the evidence on the effect of the current therapies over the pathophysiological and clinical characteristics of patients with hypertrophic cardiomyopathy (HCM). Methods and results A systematic review and meta-analysis of 41 studies identified from 1383 retrieved from PubMed, Web of Science, and Cochrane was conducted. Therapies were grouped in pharmacological, invasive and physical exercise. Pharmacological agents had no effect on functional capacity measured by VO2max (1.11 mL/kg/min; 95% CI: −0.04, 2.25, P < 0.05). Invasive septal reduction therapies increased VO2max (+3.2 mL/kg/min; 95% CI: 1.78, 4.60, P < 0.05). Structured physical exercise programmes did not report contraindications and evidenced the highest increases on functional capacity (VO2max + 4.33 mL/kg/min; 95% CI: 0.20, 8.45, P < 0.05). Patients with left ventricular outflow tract (LVOT) obstruction at rest improved their VO2max to a greater extent compared with those without resting LVOT obstruction (2.82 mL/kg/min; 95% CI: 1.97, 3.67 vs. 1.18; 95% CI: 0.62, 1.74, P < 0.05). Peak LVOT gradient was reduced with the three treatment options with the highest reduction observed for invasive therapies. Left ventricular ejection fraction was reduced in pharmacological and invasive procedures. No effect was observed after physical exercise. Symptomatic status improved with the three options and to a greater extent with invasive procedures. Conclusions Invasive septal reduction therapies increase VO2max, improve symptomatic status, and reduce resting and peak LVOT gradient, thus might be considered in obstructive patients. Physical exercise emerges as a coadjuvant therapy, which is safe and associated with benefits on functional capacity. Pharmacological agents improve reported NYHA class, but not functional capacity.
dc.formatapplication/pdf
dc.identifier.citationESC Heart Failure, Volume 10, Issue 1, February 2023, Pages 8–23
dc.identifier.doihttps://doi.org/10.1002/ehf2.14142
dc.identifier.eissn2055-5822
dc.identifier.urihttp://hdl.handle.net/10201/201009
dc.languageeng
dc.publisherOxford University Press
dc.relationSociedad Española de Cardiología-FEC (strategic investigation projects), PI MSM, 2017.
dc.relation.publisherversionhttps://academic.oup.com/eschf/article/10/1/8/8304965
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHypertrophic cardiomyopathy
dc.subjectFunctional capacity
dc.subjectLeft ventricular outflow tract obstruction
dc.subjectCardiopulmonary exercise test
dc.subjectTherapies
dc.subject.odsObjetivo 3: Salud
dc.titleCurrent therapies for hypertrophic cardiomyopathy: a systematic review and meta-analysis of the literature
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublicationf4a8b11b-9980-45e4-9d87-c430bde8beb2
relation.isAuthorOfPublication4d37f6b7-66c0-4f9a-81c7-72d9bd67f2fb
relation.isAuthorOfPublication6a642dfb-d0e6-4dcf-ae7e-c19949e99a85
relation.isAuthorOfPublication.latestForDiscoveryf4a8b11b-9980-45e4-9d87-c430bde8beb2
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2022 - ESC Heart Failure - Current therapies for hypertrophic cardiomyopathy a.pdf
Size:
1.4 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.37 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos