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An Upgrade on the Rabbit Model of Anthracycline-Induced Cardiomyopathy: Shorter Protocol, Reduced Mortality, and Higher Incidence of Overt Dilated Cardiomyopathy

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dc.contributor.authorTalavera López, Jesús
dc.contributor.authorGiraldo, Alejandro
dc.contributor.authorFernández del Palacio, María Josefa
dc.contributor.authorGarcía-Nicolás, Obdulio
dc.contributor.authorBrooks, Gavin
dc.contributor.authorMoraleda, Jose María
dc.contributor.authorSeva Alcaraz, Juan
dc.contributor.departmentMedicina y Cirugía Animal
dc.coverage.spatialEspañaes
dc.coverage.temporal2015es
dc.date.accessioned2024-01-29T11:39:04Z
dc.date.available2024-01-29T11:39:04Z
dc.date.issued2015-12-01
dc.descriptionCopyright © 2015 Jesus Talavera et al. This is an open access article distributed under the Creative Commons Attribution License, ´ which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.description.abstractCurrent protocols of anthracycline-induced cardiomyopathy in rabbits present with high premature mortality and nephrotoxicity, thus rendering them unsuitable for studies requiring long-term functional evaluation of myocardial function (e.g., stem cell therapy). We compared two previously described protocols to an in-house developed protocol in three groups: Group DOX2 received doxorubicin 2 mg/kg/week (8 weeks); Group DAU3 received daunorubicin 3 mg/kg/week (10 weeks); and Group DAU4 received daunorubicin 4mg/kg/week (6 weeks). A cohort of rabbits received saline (control). Results of blood tests, cardiac troponin I, echocardiography, and histopathology were analysed. Whilst DOX2 and DAU3 rabbits showed high premature mortality (50% and 33%, resp.), DAU4 rabbits showed 7.6% premature mortality. None of DOX2 rabbits developed overt dilated cardiomyopathy; 66% of DAU3 rabbits developed overt dilated cardiomyopathy and quickly progressed to severe congestive heart failure. Interestingly, 92% of DAU4 rabbits showed overt dilated cardiomyopathy and 67% developed congestive heart failure exhibiting stable disease. DOX2 and DAU3 rabbits showed alterations of renal function, with DAU3 also exhibiting hepatic function compromise. Thus, a shortened protocol of anthracycline-induced cardiomyopathy as in DAU4 group results in high incidence of overt dilated cardiomyopathy, which insidiously progressed to congestive heart failure, associated to reduced systemic compromise and very low premature mortality.es
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.doihttp://dx.doi.org/10.1155/2015/465342
dc.identifier.issnPrint 2314-6133
dc.identifier.issnElectronic 2314-6141
dc.identifier.urihttp://hdl.handle.net/10201/137937
dc.languageenges
dc.relationFundacio ́n Se ́neca, Agencia de Ciencia y Tec- nolog ́ıa, Regio ́n de Murcia, Spain (Jesu ́s Talavera) (Grant no. 11935/PI/09), Red de Terapia Celular, ISCIII-Sub. Gral. Redes, VI PN de I+D+I 2008-2011 (Grant no. RD12/0019/0001) (Jose ́ M. Moraleda), Cofinanciado con Fondos Estructurales de la Unio ́n Europea (FEDER) (Jose ́ M. Moraleda), and University of Reading, United Kingdom (Alejandro Giraldo and Gavin Brooks) (central funding).es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleAn Upgrade on the Rabbit Model of Anthracycline-Induced Cardiomyopathy: Shorter Protocol, Reduced Mortality, and Higher Incidence of Overt Dilated Cardiomyopathyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationf4f4c0d0-67f8-43f4-afa3-7bf3d0f3c03a
relation.isAuthorOfPublication.latestForDiscoveryf4f4c0d0-67f8-43f4-afa3-7bf3d0f3c03a
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