Publication:
Quantitative neuromuscular ultrasound analysis as biomarkers in amyotrophic lateral sclerosis

Simple item page
dc.contributor.authorMartínez Payá, Jacinto Javier
dc.contributor.authorVázquez-Costa, Juan F.
dc.contributor.authorChumillas, Maria J.
dc.contributor.authorTembl Ferrairó, José I.
dc.contributor.authorBaño Aledo, María Elena del
dc.contributor.authorRíos Díaz, José
dc.contributor.departmentFisioterapia
dc.date.accessioned2024-02-01T09:49:24Z
dc.date.available2024-02-01T09:49:24Z
dc.date.issued2019-08
dc.description©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Submitted, Accepted, Published, version of a Published Work that appeared in final form in European Radiology . To access the final edited and published work see https://doi.org/10.1007/s00330-018-5943-8es
dc.description.abstractObjectives: To assess the differences in morphological and texture parameters of median nerve (MN) and abductor pollicis brevis (APB) between amyotrophic lateral sclerosis (ALS) patients and controls. Methods: The cross-sectional area (CSA) of the MN and the muscle thickness (MTh) of APB were measured bilaterally in 59 recently diagnosed ALS patients and 20 matched healthy controls. Echointensity (EI), echovariation (EV) and grey-level co-occurrence matrix (GLCM) texture features of both structures were also analysed. Correlations between these parameters and clinical variables (muscle strength and disability) were analysed. Results: The CSA of MN was significantly lower in ALS patients (MD = - 1.83 mm2 [95% CI = 2.89; - 0.77 mm2]; p = 0.01). ALS patients showed significantly lower MTh (- 2.23 mm [3.16; - 1.30 mm]; p < 0.001) and EV (- 7.40 [11.5; - 3.33]; p = 0.004) and higher EI (21.2 [11.9; 30.6]; p < 0.001) in the APB muscle. No relevant differences were detected in GLCM features for this muscle. The model including all parameters (CSA for MN and MTh, EI and EV for APB) showed an AUC of 82% (sensitivity 87%; specificity 42%). Muscle strength and disability correlated with APB muscle ultrasound parameters but not with those of the MN. Conclusions: APB muscle ultrasound biomarkers (especially MTh and EI) showed better discrimination capacity and correlation with clinical variables than MN biomarkers. However, the combination of both biomarkers increased their ability to detect LMN impairment, suggesting that both biomarkers could be used in a complementary manner for the diagnosis and progression monitoring in ALS.es
dc.formatapplication/pdfes
dc.format.extent31es
dc.identifier.citationEuropean Radiology 2019 Aug 29(8): p 4266-4275.
dc.identifier.doi10.1007/s00330-018-5943-8
dc.identifier.issn0938-7994
dc.identifier.issn1432-1084
dc.identifier.urihttp://hdl.handle.net/10201/138383
dc.languageenges
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAmyotrophic lateral sclerosises
dc.subjectBiomarkerses
dc.subjectUltrasonographyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleQuantitative neuromuscular ultrasound analysis as biomarkers in amyotrophic lateral sclerosises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Quantitative neuromuscular ultrasound analysis as biomarkers in ALS_R2.pdf
Size:
2.49 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos