Publication: Chemokines and their receptors in disease
Authors
Bendall, L.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Chemokines are a family of structurally
related low molecular weight (8–10 kDa) proteins that
are important for the organization of tissues during
development and regulate cell motility and localization
both during development and in the adult. In the adult,
this function is predominately related to the trafficking
of leukocytes, although more recently the impact of
these molecules on other cell types has become apparent.
Chemokines mediate their effects by binding seven
transmembrane, G-protein coupled, receptors. In
addition to their primary role in regulating cell motility,
they can also influence cell survival and proliferation.
Antagonists for a number of chemokine receptor have
been developed, raising the possibility of interfering
with chemokine function as a therapeutic tool. This
review focuses on the emerging roles for chemokines in
normal physiology and disease.
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Citation
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