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Chitosan-based nanocapsules: physical characterization, stability in biological media and capsaicin encapsulation

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dc.contributorAngela Valle-Gallego, Rossana Stefani, Bianca Menchicchi, Laurent David, Cyrille Rochas, Manuel J. Santander-Ortega & María J. Alonso
dc.contributor.authorGoycoolea Valencia, Francisco Martín
dc.contributor.authorAngela Valle-Gallego
dc.contributor.authorRossana Stefani
dc.contributor.authorBianca Menchicchi
dc.contributor.authorLaurent David
dc.contributor.authorCyrille Rochas
dc.contributor.authorManuel J. Santander-Ortega
dc.contributor.authorMaría J. Alonso
dc.contributor.departmentBiología Celular e Histología
dc.contributor.otherFacultades de la UMU::Facultad de Biología
dc.date.accessioned2026-02-05T12:08:07Z
dc.date.available2026-02-05T12:08:07Z
dc.date.copyright© Springer-Verlag 2012
dc.date.issued2012-05-08
dc.description.abstractThis study addresses the effect of the degree of Nacetylation (DA ~1.4–56 %) of chitosan (CS) of low and medium molecular weight (Mw ~9.5–13.2 and ~122–266 kDa, respectively) on the biophysical properties, colloidal stability and encapsulation efficiency of capsaicin (a lipophilic drug currently used in pain therapy) of CS-based nanocapsules (NCs). The average diameter of the NCs varied within the range of ~150–200 nm, but it was slightly higher for NCs comprising high Mw CS than for those with low Mw CS. The zeta potential (ζ) was highly positive and clearly dependent on the Mw of CS, exhibiting a monotonic decreasing trend concomitant with the increase in DA. Both results suggest that Mw and DA of CS have an effect on the disposition of the polysaccharide onto the phospholipidic surface. Synchrotron SAXS studies revealed a monotonic increase in Bragg interplanar distances (from ~55 up to ~67 Å) as a function of the DA, a finding that agrees with previous results that are consistent with the capacity of hydrophobic domains to disturb the crystalline state ofgelled phospholipidic membranes. Colloidal stability studies carried out in cell-culture biological media revealed the determinant role of hydration forces, a short-range repulsive interaction, on the stability of the NCs. Finally, Mw and DA of CS both influenced the encapsulation efficiency of capsaicin, thus showing the effect of the harnessed NCs shell on its capacity to encapsulate lipophilic drugs.
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dc.identifier.citationGoycoolea F.M., Valle-Gallego A., Stefani R., Menchicchi B., David L., Rochas C., Santander-Ortega M.J., Alonso M.J. (2012). Chitosan-based nanocapsules: physical characterization stability in biological media and capsaicin encapsulation. Colloid Polym Sci, 290, 1423-1434
dc.identifier.doihttps://doi.org/10.1007/s00396-012-2669-z
dc.identifier.urihttp://hdl.handle.net/10201/200130
dc.languageeng
dc.publisherSpringer-Verlag
dc.relationSupport from the European Union for projects Nanobiosaccharides (ref. no. 013882 FP6) and BioNanoSmart-DDS (ref. no. 908111 FP7-PEOPLE Programme Marie Curie); from European Synchrotron Research Facility (France) for project ref. SC2774; from “Ministerio de Ciencia e Innovación” (Spain) for project Consolider Nanobiomed (ref. no. CSD 2006–00012); from the “Consejería de Innovación, Ciencia y Tecnología de la Junta de Andalucía” (Spain) for projects P07-FQM-2496 and P07-FQM-03099 and from “Xunta de Galicia” (Spain) for a research fellowship to one of us (MJS) (Ángeles Alvariño research programme ref. IN840D)
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCapsaicin . Chitosan . Nanocapsules . Synchrotron SAXS . Stability
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleChitosan-based nanocapsules: physical characterization, stability in biological media and capsaicin encapsulation
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
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relation.isAuthorOfPublication.latestForDiscoveryb9a16197-ec5b-45bf-a4a5-e0a4499b7d58
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