Cadmium- and lead-induced apoptosis in mallard erythrocytes (Anas platyrhynchos)

Romero García, Diego; Hernández-García, A.; Tagliati, C. A.; Martínez-López, E.; García Fernández, Antonio Juan

Publication:
Cadmium- and lead-induced apoptosis in mallard erythrocytes (Anas platyrhynchos)

dc.contributor.author	Romero García, Diego
dc.contributor.author	Hernández-García, A.
dc.contributor.author	Tagliati, C. A.
dc.contributor.author	Martínez-López, E.
dc.contributor.author	García Fernández, Antonio Juan
dc.contributor.department	Ciencias Sociosanitarias
dc.date.accessioned	2024-03-08T08:15:16Z
dc.date.available	2024-03-08T08:15:16Z
dc.date.issued	2009-01
dc.description	©2008 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published version of a Published Work that appeared in final form in Ecotoxicology and Environmental Safety. To access the final edited and published work see https://doi.org/10.1016/j.ecoenv.2008.05.004	es
dc.description.abstract	Cadmium, lead and cadmium–lead (1:10) induced apoptosis were studied using mallard blood cells. The allowable range in concentrations were: 0.01–0.5, 0.1–5.0, and 0.01:0.10–0.50:5.00 mM, for cadmium, lead and cadmium–lead, respectively. The lowest EC50 achieved was for cadmium (0.2270.04 mM). Two doses from each treatment group were chosen to study apoptosis and the presence of metals in cells. The percentage of apoptotic cells increased as the concentration of metals increased. The percentage of cells with intracellular metals was high for both exposure levels and the quantity of intracellular metal was greater for exposure to high concentrations. Morphological alterations for all types of exposure were related to the diverse range of effects that these metals have on membranes. We suggest that the decrease in the number of erythrocytes observed in specimens suffering from lead and cadmium poisoning is related to the induction of apoptosis.	es
dc.format	application/pdf	es
dc.format.extent	8	es
dc.identifier.citation	Ecotoxicology and Environmental Safety, Vol. 72, N. 1, 2009, 37– 44
dc.identifier.doi	https://doi.org/10.1016/j.ecoenv.2008.05.004
dc.identifier.issn	Print: 0147-6513
dc.identifier.uri	http://hdl.handle.net/10201/140010
dc.language	eng	es
dc.publisher	Elsevier	es
dc.relation	This study received backing from CICYT/FEDER Project CGL2004-5959 (MASCA’2004). Thanks to Pedro María Mojica and Pilar Gómez Ramírez for collecting blood samples. Thanks also to the Consellería de Territori i Habitatge de la Generalitat Valenciana for providing said samples.	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0147651308001383?via%3Dihub	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Lead	es
dc.subject	Cadmium	es
dc.subject	Erythrocytes	es
dc.subject	Flow cytometry	es
dc.subject	Microscopy	es
dc.subject	Viability	es
dc.subject	Apoptosis	es
dc.title	Cadmium- and lead-induced apoptosis in mallard erythrocytes (Anas platyrhynchos)	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
relation.isAuthorOfPublication	a0c84987-f342-48dc-973c-912958efee27
relation.isAuthorOfPublication.latestForDiscovery	a0c84987-f342-48dc-973c-912958efee27