Publication: Appearance of vascular endothelial growth factor (VEGF) in femoral head in the growing rat
Authors
Ichigatani, M. ; Saga, T. ; Yamaki, K. ; Yoshizuka, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In this study, we examined the appearance of
vascular endothelial growth factor (VEGF) in the
femoral head of the growing rat using an
immunocytochemical technique. Our results showed
VEGF-immunopositive cells existed in the inner region
and peripheral region of the femoral head at each
developmental stage. In the 19-day-old fetus,
immunopositive mesenchymal cells were demonstrated
in the peripheral region of the femoral head. At 1 to 10
days after birth, VEGF immunoreactivities were
observed in the osteoblasts, osteoclasts, periosteum,
perichondrium and cartilage matrix of the femur. At 15
days after birth, VEGF immunoreactive chondrocytes
appeared in the apex area of the femoral head. In this
stage, the femoral head is still constituted by
chondrocytes and no apparent vascular formation has
been observed. Thereafter, the immunopositive
chondrocytes in the femoral head increased in number.
The penetration of capillaries was recognized within the
ligament of the femoral head at 60 days after birth. The
results indicate that some chondrocytes in the femoral
head produce VEGF before the beginning of
ossification, and that VEGF may play an important role
in the penetration of blood vessels into the femoral head
from the ligament of the femoral head.
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