Publication: Simultaneous bilateral breast carcinoma:
Histopathological characteristics and
CD44/catenin-cadherin profile
Authors
Bassarova, A.V. ; Torlakovic, E. ; Sedloev, T. ; Hristova, S.L. ; Trifonov, D.Y. ; Nesland, Jahn M.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Aims: Family history of breast carcinoma,
multicentric tumor foci in one breast, and in situ lobular
carcinoma increase the risk of bilateral breast cancer
(BBC), synchronous or metachronous. Synchronous
tumors are designated as simultaneous breast carcinoma
if they appear at the same time. The CD44 family and
cadherin/catenin immunophenotype of this group of
BBCs has not yet been evaluated. The aim of this study
was to compare clinicopathological characteristics and
immunohistochemical profiles of simultaneous BBC and
corresponding lymph node metastases in eight patients.
Methods and results: In toto 15 primary and 9 metastatic
tumors were evaluated. The expression of CD44 variant
isoforms, ß-catenin, E, P and N-cadherin were evaluated
by immunohistochemistry. Rare types of breast
carcinoma were frequent in this group of patients. There
were 6 pleomorphic lobular, 5 invasive ductal of usual
type, 3 atypical medullary carcinomas, 2 mucinous and
one invasive micropapillary carcinoma. The expression
CD44v6 was most frequent, followed by CD44v3-10,
CD44v5, and CD44v3. CD44v4 was generally not
expressed. E-cadherin was expressed in 80% primary
tumors, 40% expressed N-cadherin, and 66% expressed
P-cadherin. Conclusions: Generally, simultaneous
carcinomas had different morphology and different
immunophenotype. Each primary tumor was more
similar to its corresponding metastatic tumor than to the
contralateral primary tumor.
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.