Publication: Effects of bombesin and neuromedin-B on the proliferative activity of the rat adrenal cortex
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Date
1993
Authors
Markowska, A. ; Nussdorfer, G.G. ; Malendowicz, L.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Bombesin (BM) and neuromedin-B (NMB)
exert similar biological effects, acting via two
functionally distinct BM-receptor subtypes. The present
study aimed to investigate whether BM and NMB
stimulate the proliferation of rat adrenocortical cells and
to compare their mode of action. Adult female rats were
treated with a single subcutaneous dose of 3 pg BM or
NMB. Adrenocortical proliferative activity was assessed
by the metaphase-arrest technique. BM administration
resulted in a marked increase in the number of
metaphases in zona glomerulosa (ZG) and zona
fasciculata (ZF), and in the entire cortex. This increase
appeared 24 h after injection in the ZG, and after 48 h in
the ZF. NMB adrninistration, on the other hand, caused a
prompt increase in the number of metaphases in the ZG
and entire cortex at 12 h, followed by a subsequent drop
below the control leve1 at 24 and 48 h of experiment.
These findings indicate that BM and NMB enhance the
proliferative activity of rat adrenocortical cells acting via
different receptors or different mediators.
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