Publication: Regulation of tumor cell invasion by extracellular matrix
Authors
Crowe, D.L. ; Shuler, C.F.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The ability of malignant tumor cells to
invade normal surrounding tissue contributes in large
part to the significant morbidity and mortality of these
cancers. The process of invasion involves adherence of
the tumor cells to the extracellular matrix (ECM),
degradation of matrix components, and movement of the
cell body. Attachment to ECM molecules is mediated by
the integrin family of extracellular matrix receptors.
Integrins are a large family of heterodimeric proteins
which transduce a variety of signals from the ECM.
Ligand occupancy is critical for activation of integrin
signaling. This signaling may occur via several different
pathways. One of the best characterized of these pathways
is the mitogen activated protein kinase (MAPK)
cascade. This serial phosphorylation of substrate
proteins terminates in activation of transcription factors
which regulate expression of target genes. Many of these
genes are critical for extracellular matrix degradation or
cell migration. Among these are the matrix metalloproteinases
(MMPs), a large family of ECM-degrading
enzymes. Regulatory elements in the promoters of
MMPs have been characterized, providing insight into
how MMP expression is controlled. This review focuses
on mechanisms by which the ECM regulates tumor cell
invasion through integrin signaling via the MAPK
pathway using MMP expression as the model.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.