Publication:
Has_circ_0071803 promotes colorectal cancer progression by regulating miR-330-5p/MAPK signaling pathway

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4f6b01ce-dad4-44fe-91b3-27eadca8edaa-8.pdf(8.47 MB)
Date
2023
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Authors
Huang, Liyong ; Dou, Guangjian ; Lu, Jiajun ; Chen, Zhiheng ; Wang, Jiayi
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-598
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info:eu-repo/semantics/article
Description
Abstract
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. A lack of effective targeted therapies against CRC makes the treatment challenging. Here, we report a circular RNA (circRNA), has_circ_0071803, functioning as an oncogene in CRC. Circ_0071803 was upregulated in CRC tissues and cell lines, and its expression levels were inversely correlated with the prognosis and survival rate of patients with CRC. Circ_0071803 knockdown suppressed cell proliferation, migration, and invasion in CRC. Moreover, we found that circ_0071803 sponged miR-330-5p, thereby upregulating mitogen-activated protein kinase 1 (MAPK1) in CRC cells. The suppression of cell activities by circ_0071803 knockdown were rescued by miR-330-5p inhibition or MAPK1 overexpression. Collectively, our findings elucidate that circ_0071803 promotes CRC progression by regulating the miR-330-5p/MAPK1 pathway, providing potential therapeutic targets for designing effective targeted treatments
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Colorectal cancer , Circ_0071803 , MiR-3305p/MAPK1 , Proliferation , Metastasis
Citation
Histology and Histopathology Vol. 38, nº12 (2023)
URI
http://hdl.handle.net/10201/136287
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Histology and histopathology Vol.38,nº12 (2023)
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