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Evaluation of tissue response and genotoxicity of poly(L/D-lactic acid) disks implanted in rat calvarium

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dc.contributor.authorGonçalves Göelze, Juliana
dc.contributor.authorLinard Avelar, Rafael
dc.contributor.authordo Nascimento Dolzan, André
dc.contributor.authorEmmel Becker, Otávio
dc.contributor.authorHaas Junior, Orion Luiz
dc.contributor.authorde Oliveira, Luciane Yumi Suzuki
dc.contributor.authorde Oliveira, Rogério Belle
dc.date.accessioned2017-11-09T17:24:37Z
dc.date.available2017-11-09T17:24:37Z
dc.date.issued2012
dc.description.abstractThe aim of the present study was to evaluate local and cytotoxicity systemic tissue reaction in the skull of rats using the implantation of disks of poly (lactic L/D-acid) and evaluate its genotoxicity. 25 males Wistar rats were used, 20 animals underwent surgical procedures and had the discs implanted in the parietal bone, and 5 animals received postoperative medication in the same way, serving as a control group for genotoxicity. The results were subjected to statistical evaluation by analysis of variance (ANOVA). In histological evaluation, between periods of 90 and 120 days in the control group, a new formation at the edges of the defect was noticed. In the experimental group, there was new bone formation at the edges of the defect, migrating below the site occupied by the disk, an absence of inflammatory infiltrate. Regarding the evaluation of genotoxicity, a significant reduction in the frequency of polychromatic erythrocytes in relation to negative control or significant increase in the polychromatic erythrocytes with micronuclei was not detected. So, the material used in this study is biocompatible and well tolerated by the tissues studied, and found to be negative for chromosomal mutagenicity.es
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dc.format.extent7es
dc.identifier.citationHistology and histopathology, Vol. 27, n.º 12 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/54479
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectBone regenerationes
dc.subjectGenotoxicityes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleEvaluation of tissue response and genotoxicity of poly(L/D-lactic acid) disks implanted in rat calvariumes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº12 (2012)