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Chitinase-3-Like Protein 1, Serum Amyloid A1, C-Reactive Protein, and Procalcitonin are promising biomarkers for intracranial severity assessment of traumatic brain injury: relationship with Glasgow Coma Scale and computed tomography volumetry

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dc.contributor.authorSánchez Carabias, Cristina
dc.contributor.authorGómez, Pedro A.
dc.contributor.authorPanero, Irene
dc.contributor.authorCastaño León, Ana María
dc.contributor.authorEiriz, Carla
dc.contributor.authorEgéa, Javier
dc.contributor.authorLagares, Alfonso
dc.contributor.authori+12 Neurotraumatology Group Collaborators
dc.contributor.authorParedes, Igor
dc.contributor.authorFernández Alén, José Antonio
dc.contributor.authorMoreno Gómez, Luis Miguel
dc.contributor.authorGarcía Pérez, Daniel
dc.contributor.authorChico Fernández, Mario
dc.contributor.authorBarea Mendoza, Jesús Abelardo
dc.contributor.departmentFarmacología
dc.contributor.otherFacultades de la UMU::Facultad de Medicina
dc.date.accessioned2026-02-19T09:14:26Z
dc.date.available2026-02-19T09:14:26Z
dc.date.copyright© 2019 Elsevier Inc.
dc.date.issued2020-02-11
dc.description.abstractObjective The volume and location of intracranial hematomas are well-known prognostic factors for traumatic brain injury. The aim of this study was to determine the relationship of serum biomarkers S100β, glial fibrillary acidic protein, neuron-specific enolase, total tau, phosphorylated neurofilament heavy chain, serum amyloid A1 (SAA1), C-reactive protein, procalcitonin (PCT), and chitinase-3-like protein 1 (YKL-40) with traumatic brain injury severity and the amount and location of hemorrhagic traumatic lesions. Methods A prospective observational cohort of 115 patients with a Glasgow Coma Scale (GCS) score of 3–15 were evaluated. Intracranial lesion volume was measured from the semiautomatic segmentation of hematoma on computed tomography using Analyze software. The establishment of possible biomarker cutoff points for intracranial lesion detection was estimated using the Youden Index (J) obtained from the area under the receiver operating characteristic curve. Results SAA1, YKL-40, PCT, and S100β showed the most robust association with level of consciousness, both with total GCS and motor score. Biomarkers significantly correlated with volumetric measurements of subdural hematoma, traumatic subarachnoid hemorrhage, intraparenchymal hemorrhage, intraventricular hemorrhage, and total amount of bleeding. The type of intracranial hemorrhage was associated with various release patterns of neurobiochemical markers. Conclusions YKL-40, SAA1, C-reactive protein, and PCT combined with S100β were the most promising biomarkers to determine the presence, location, and extent of traumatic intracranial lesions. Combination of biomarkers further increased the discriminatory capacity for the detection of intracranial bleeding.
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dc.format.extent24
dc.identifier.citationWorld Neurosurgery, 2020, Vol. 134, pp. e120-e143
dc.identifier.doihttps://doi.org/10.1016/j.wneu.2019.09.143
dc.identifier.eissn1878-8769
dc.identifier.issn1878-8750
dc.identifier.urihttp://hdl.handle.net/10201/208041
dc.languageeng
dc.publisherElsevier
dc.relationThis work was supported by grants from Fondo de Investigaciones Sanitarias (FIS) (ISCIII/FEDER) (grant numbers PI18/01387, PI14/01457) to A.L.; Programa Miguel Servet (grant number CP14/00008); and Fundación Mutua Madrileña (grant number PI16/00735) to J.E.
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1878875019325872
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCT volumetry
dc.subjectGlasgow Coma Scale
dc.subjectIntracranial hemorrhage
dc.subjectTraumatic brain injury
dc.subjectBiomarkers
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleChitinase-3-Like Protein 1, Serum Amyloid A1, C-Reactive Protein, and Procalcitonin are promising biomarkers for intracranial severity assessment of traumatic brain injury: relationship with Glasgow Coma Scale and computed tomography volumetry
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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relation.isAuthorOfPublication.latestForDiscovery2f2500a1-1b27-4420-820c-db8c16e79afd
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