Publication:
Systematic Review and Meta-Analysis: An Empirical Approach to Defining Treatment Response and Remission in Pediatric Obsessive-Compulsive Disorder

Simple item page
dc.contributor.authorFarhat, Luis C.
dc.contributor.authorVattimo, Edoardo F. Q.
dc.contributor.authorRamakrishnan, Divya
dc.contributor.authorLevine, Jessica L.S.
dc.contributor.authorJohnson, Jessica A.
dc.contributor.authorArtukoglu, Bekir B.
dc.contributor.authorLanderos-Weisenberger, Angeli
dc.contributor.authorAsbahr, Fernando R.
dc.contributor.authorCepeda, Sandra L.
dc.contributor.authorComer, Jonathan S.
dc.contributor.authorFatori, Daniel
dc.contributor.authorFranklin, Martin E.
dc.contributor.authorFreeman, Jennifer B.
dc.contributor.authorGeller, Daniel A.
dc.contributor.authorGoodman, Wayne K.
dc.contributor.authorHeyman, Isobel
dc.contributor.authorIvarsson, Tord
dc.contributor.authorLenhard, Fabian
dc.contributor.authorLewin, Adam B.
dc.contributor.authorLi, Fenghua
dc.contributor.authorMerlo, Lisa J.
dc.contributor.authorMohsenabadi, Hamid
dc.contributor.authorPeris, Tara S.
dc.contributor.authorPiacentini, John
dc.contributor.authorRosa-Alcázar, Ana Isabel
dc.contributor.authorRosa-Alcázar, Ángel
dc.contributor.authorRozenman, Michelle
dc.contributor.authorSapyta, Jeffrey J.
dc.contributor.authorSerlachius, Eva
dc.contributor.authorShabani, Mohammad J.
dc.contributor.authorShavitt, Roseli G.
dc.contributor.authorSmall, Brent J.
dc.contributor.authorSkarphedinsson, Gudmundur
dc.contributor.authorSwedo, Susan E.
dc.contributor.authorThomsen, Per Hove
dc.contributor.authorTurner, Cynthia
dc.contributor.authorWeidle, Bernhard
dc.contributor.authorEuripides C., Miguel
dc.contributor.authorStorch, Eric A.
dc.contributor.authorMataix-Cols, David
dc.contributor.authorBloch, Michael H.
dc.contributor.authorGrant, Paul J.
dc.contributor.departmentPersonalidad, Evaluación y Tratamiento Psicológicos
dc.coverage.spatialInternacionales
dc.date.accessioned2024-01-30T11:52:29Z
dc.date.available2024-01-30T11:52:29Z
dc.date.issued2022
dc.description©<2022>. This manuscript version is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the, Submitted, version of a Published Work that appeared in final form in Journal of the American Academy of Child and Adolescent Psychiatry. To access the final edited and published work see: https://doi.org/10.1016/j.jaac.2021.05.027
dc.description.abstractObjective: A lack of universal definitions for response and remission in pediatric obsessive- compulsive disorder (OCD) has hampered the comparability of results across trials. To address this problem, we conducted an individual participant data diagnostic test accuracy meta-analysis to evaluate the discriminative ability of the Children’s Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) in determining response and remission. We also aimed to generate empirically derived cutoffs on the CY-BOCS for these outcomes. Method: A systematic review of PubMed, PsycINFO, Embase and CENTRAL identified 5,401 references, 42 randomized controlled clinical trials (RCTs) were considered eligible and 21 provided data for inclusion (N 1,234). A score ≤ 2 in the Clinical Global Impressions Improvement and Severity scales were chosen to define response and remission, respectively. A two-stage random-effects meta-analysis model was established. The area under the curve (AUC) and the Youden Index were computed to indicate the discriminative ability of the CY-BOCS and to guide for the optimal cutoff, respectively. Results: The CY-BOCS had sufficient discriminative ability to determine response (AUC 0.89) and remission (AUC 0.92). The optimal cutoff for response was a ≥ 35% reduction from baseline to posttreatment (sensitivity [95% CI] 83.9 [83.7, 84.1]; specificity [95% CI] 81.7 [81.5, 81.9]). The optimal cutoff for remission was a posttreatment raw score ≤ 12 (sensitivity [95% CI] 82.0 [81.8, 82.2]; specificity [95% CI] 84.6 [84.4, 84.8]). Conclusion: Meta-analysis identified empirically optimal cutoffs on the CY-BOCS to determine response and remission in pediatric OCD RCTs. Systematic adoption of standardized operational definitions for response and remission will improve comparability across trials for pediatric OCD.es
dc.formatapplication/pdfes
dc.format.extent38es
dc.identifier.citationJournal of the American Academy of Child & Adolescent Psychiatry Volume 61, Issue 4, April 2022, Pages 495-507
dc.identifier.doihttps://doi.org/10.1016/j.jaac.2021.05.027
dc.identifier.issn2949-7329
dc.identifier.urihttp://hdl.handle.net/10201/138138
dc.languageenges
dc.publisherElsevieres
dc.relationMinistry of Economy and Competitiveness of the Spanish Government (Project PSI2016-78185-P) and the Science Agency and Technology (Seneca Foundation, Region of Murcia, Projet 20902/PI/18)es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0890856721018438es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectObsessive-compulsive disorderen
dc.subjectRandomized controlled trialsen
dc.subjectMeta-analysisen
dc.subjectDiagnostic test accuracyen
dc.subject.otherCDU::1 - Filosofía y psicologíaes
dc.titleSystematic Review and Meta-Analysis: An Empirical Approach to Defining Treatment Response and Remission in Pediatric Obsessive-Compulsive Disorderes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.subjectCy-bocsen
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Systematic Review and Meta-Analysis An Empirical Approach.pdf
Size:
1.37 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos