Publication:
Durability of bioprosthetic aortic valve replacement in patients under the age of 60 years — 1-year follow-up from the prospective INDURE registry

Simple item page
dc.contributor.authorMeuris, Bart
dc.contributor.authorRoussel, Jean-Christian
dc.contributor.authorBorger, Michael A.
dc.contributor.authorSiepe, Matthias
dc.contributor.authorStefano, Pierluigi
dc.contributor.authorLaufer, Günther
dc.contributor.authorLanganay, Thierry
dc.contributor.authorTheron, Alexis
dc.contributor.authorGrabenwöger, Martin
dc.contributor.authorBinder, Konrad
dc.contributor.authorDemers, Philippe
dc.contributor.authorPesotto, Renzo
dc.contributor.authorLeeuwen, Wouter van
dc.contributor.authorBourguignon, Thierry
dc.contributor.authorCánovas López, Sergio
dc.contributor.authorMariscalco, Giovanni
dc.contributor.authorCoscioni, Enrico
dc.contributor.authorDagenais, Francois
dc.contributor.authorWendler, Olaf
dc.contributor.authorPolvani, Gianluca
dc.contributor.authorEden, Matthias
dc.contributor.authorBotta, Beate
dc.contributor.authorBramlage, Peter
dc.contributor.authorDe Paulis, Ruggero
dc.contributor.departmentCirugía, Pediatría y Obstetricia y Ginecología
dc.date.accessioned2024-07-18T08:34:16Z
dc.date.available2024-07-18T08:34:16Z
dc.date.issued2023-07-18
dc.description© The Author(s) 2023. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Interdisciplinary CardioVascular and Thoracic Surgery. To access the final edited and published work see https://doi.org/10.1093/icvts/ivad115
dc.description.abstractOBJECTIVES: We report 1-year safety and clinical outcomes in patients <60 years undergoing bioprosthetic surgical aortic valve intervention. METHODS: The INSPIRIS RESILIA Durability Registry is a prospective, multicentre registry to assess clinical outcomes of patients <60 years. Patients with planned SAVR with or without concomitant replacement of the ascending aorta and/or coronary bypass surgery were included. Time-related valve safety, haemodynamic performance and quality of life (QoL) at 1 year were assessed. RESULTS: A total of 421 patients were documented with a mean age of 53.5 years, 76.5% being male and 27.2% in NYHA class III/IV. Outcomes within 30 days included cardiovascular-related mortality (0.7%), time-related valve safety (VARC-2; 5.8%), thromboembolic events (1.7%), valve-related life-threatening bleeding (VARC-2; 4.3%) and permanent pacemaker implantation (3.8%). QoL was significantly increased at 6 months and sustained at 1 year. Freedom from all-cause mortality at 1 year was 98.3% (95% confidence interval 97.1; 99.6) and 81.8% were NYHA I versus 21.9% at baseline. No patient developed structural valve deterioration stage 3 (VARC-3). The mean aortic pressure gradient was 12.6 mmHg at 1 year and the effective orifice area was 1.9 cm2. CONCLUSIONS: The 1-year data from the INSPIRIS RESILIA valve demonstrate good safety and excellent haemodynamic performance as well as an early QoL improvement.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationInterdisciplinary CardioVascular and Thoracic Surgery 2023, 37(4), ivad115
dc.identifier.doihttps://doi.org/10.1093/icvts/ivad115
dc.identifier.issn2753-670X
dc.identifier.urihttp://hdl.handle.net/10201/143183
dc.languageenges
dc.publisherOxford University Press
dc.relationThis work was supported with a research grant (HVT-I18-331) provided by Edwards Lifesciences (Nyon, Switzerland) to the sponsor IPPMed (Cloppenburg, Germany).
dc.relation.publisherversionhttps://academic.oup.com/ejcts/article/60/3/681/6190381?login=true
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSurgical aortic valve replacementes
dc.subjectStructural valve degenerationes
dc.subjectValve durabilityes
dc.titleDurability of bioprosthetic aortic valve replacement in patients under the age of 60 years — 1-year follow-up from the prospective INDURE registryes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ivad115.pdf
Size:
877.04 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos