Publication:
Effects of long-term individual housing of middle-aged female Octodon degus on spatial learning and memory in the Barnes maze task

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dc.contributor.authorBaño Otalora, Beatriz
dc.contributor.authorRol de Lama, María de los Ángeles
dc.contributor.authorVenero, César
dc.contributor.authorMadrid, Juan Antonio
dc.contributor.authorPopovic, Natalija
dc.contributor.authorPopovic Popovic, Miroljub
dc.contributor.departmentFisiología
dc.date.accessioned2025-05-12T10:09:26Z
dc.date.available2025-05-12T10:09:26Z
dc.date.issued2023-08-03
dc.description© 2023 Popović, Baño-Otalora, Rol, Venero, Madrid and Popović. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Frontiers in Behavioral Neuroscience. To access the final edited and published work see https://doi.org/10.3389/fnbeh.2023.1221090es
dc.description.abstractIntroduction: Prolonged social isolation is a form of passive chronic stress that has consequences on human and animal behavior. The present study was undertaken to elucidate whether the long-term isolation would precipitate age-related changes in anxiety and spatial learning and memory in degus. Methods: We investigated the effects of long-term social isolation on anxiety levels in the light-dark test, and spatial orientation abilities in the Barnes maze. Middle-aged female Octodon degus were allocated to either group-housed (3 animals per cage) or individually-housed for 5 months. Results: Under this experimental condition, there were no significant group differences in the anxiety level tested in the light-dark test and in the motivation to escape from the Barnes maze. There were no significant differences in cortisol levels between individually- and group-housed animals. On the last acquisition training day of spatial learning, individually- housed animals had a significantly higher number of correct responses and a smaller number of reference and working memory errors than the group-housed animals. In addition, isolated animals showed a tendency for reference and working memory impairment on the retention trial, while group-housed degus showed improvement in these parameters. Discussion and conclusion: The present study indicates that prolonged social isolation during adulthood in female degus has a dual effect on spatial orientation. Specifically, it results in a significant improvement in acquisition skills but a slight impairment in memory retention. The obtained cognitive changes were not accompanied by modification in anxiety and cortisol levelses
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dc.format.extent10es
dc.identifier.citationFrontiers in Behavioral Neuroscience, 2023, Vol. 17 : 1221090
dc.identifier.doihttps://doi.org/10.3389/fnbeh.2023.1221090
dc.identifier.issnElectronic:1662-5153
dc.identifier.urihttp://hdl.handle.net/10201/154392
dc.languageenges
dc.publisherFrontiers Mediaes
dc.relationThis research was funded by the Ministry of Economy and Competitiveness, the Instituto de Salud Carlos III through a CIBERFES grant (CB16/10/00239); Diabfrail LatAm (European Union Horizon 2020 research and innovation programme No. 825546) awarded to MR (all co-financed by FEDER); Grant RTI2018-093528-B-I00, funded by MCIN/AEI/10.13039/501100011033; “ERDF A way of making Europe,” by the “European Union NextGenerationEU/PRTR,” and by Spanish Ministry of Science, Innovation, and Universities (PID2021-125945OB-100) awarded to CV.es
dc.relation.publisherversionhttps://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2023.1221090/fulles
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBarnes mazees
dc.subjectLight dark testes
dc.subjectOctodon deguses
dc.subjectSocial isolationes
dc.subjectAnxietyes
dc.subjectLearning and memoryes
dc.titleEffects of long-term individual housing of middle-aged female Octodon degus on spatial learning and memory in the Barnes maze taskes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationdc3015b4-805d-4b6e-a49f-f2d73bb3c2b2
relation.isAuthorOfPublication43b53091-f5bf-4b46-b164-88d2a3670e2f
relation.isAuthorOfPublication.latestForDiscoverydc3015b4-805d-4b6e-a49f-f2d73bb3c2b2
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