Publication: Immunohistochemical expression of glycodelin in breast cancer correlates with estrogen-receptor α
and progesterone-receptor A positivity
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Date
2009
Authors
Scholz, Christoph ; Toth, Bettina ; Barthell, Elisabeth ; Mylonas, I. ; Weissenbacher, Tobias ; Friese, Klaus ; Jeschke, Udo
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Glycodelin (Gd), previously known as
placental protein 14 (PP 14), acts as an immunosuppressive glycoprotein by suppressing the cytolytic
capacity of human natural killer (NK) cells and T-cells in
vitro. Glycodelin is expressed in normal glandular
epithelium of the endometrium as well as in normal and
malignant glandular cells in and outside of the
reproductive tract. Recently, Gd expression was
demonstrated in normal and cancerous human breast
tissue.
Paraffin-embedded breast cancer tissue blocks
(n=121) were examined for Gd expression. No part of
the specimens contained carcinoma in situ.
Gd expression was present in lobular and ductal
breast carcinoma. We observed expression of Gd in
breast cancer independent of grading. With regard to
nodal status, no significant differences in the expression
of Gd between cancer tissue from patients with or
without axillary lymph node metastases were present.
However, Gd expression was found to be significantly
higher in breast cancer tissue when the staining reaction
for steroid receptors was also positive.
These results implicate that Gd might be an
additional marker for the differentiation of breast cancer
tissue. To which extent Gd could serve as an additional
indicator for breast cancer survival is part of our ongoing
research.
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