Publication: Roles of versican in cancer biology -
tumorigenesis, progression and metastasis
Authors
Du, William Weidong ; Yang, Weining ; Yee, Albert J.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Versican, a large extracellular matrix
proteoglycan accumulates in tumor stroma and plays a
key role in both malignant transformation and tumor
progression. Increased versican expression has been
observed in a wide range of malignant tumors, and has
been associated with both cancer relapse and poor
patient outcomes in breast, prostate, and many other
cancer types. Through negatively-charged chondroitin
and dermatan sulfate side chains or interactions of the
G1 and G3 domains, versican is able to regulate many
cellular processes including cell adhesion, proliferation,
apoptosis, migration, angiogenesis, invasion and
metastasis. In this review, the biological roles that
versican plays in cancer development are presented.
Therapeutic targeting of versican in malignant tumors is
also discussed.
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Citation
Histology and Histopathology, vol. 28, nº 6, (2013)
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