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Unique expression profiles of mucin proteins in interstitial pneumonia-associated lung adenocarcinomas

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dc.contributor.authorTateishi, Yoko
dc.contributor.authorKataoka, Toshiaki
dc.contributor.authorOkudela, Koji
dc.contributor.authorNakashima, Yu
dc.contributor.authorMitsui, Hideaki
dc.contributor.authorMatsumura, Mai
dc.contributor.authorUmeda, Shigeaki
dc.contributor.authorArai, Hiromasa
dc.contributor.authorBaba, Tomohisa
dc.contributor.authorSuzuki, Takehisa
dc.contributor.authorKoike, Chihiro
dc.contributor.authorTajiri, Michihiko
dc.contributor.authorTakemura, Tamiko
dc.contributor.authorOgura, Takashi
dc.contributor.authorMasuda, Munetaka
dc.contributor.authorOhashi, Kenichi
dc.date.accessioned2022-10-24T15:05:30Z
dc.date.available2022-10-24T15:05:30Z
dc.date.issued2019
dc.description.abstractIn order to clarify idiopathic interstitial pneumonia (IIP)-associated lung adenocarcinoma (LADC), we herein focused on the expression profiles of mucin proteins, the most common cellular differentiation markers. The expression of the mucin (MUC) 1, MUC2, MUC3B, MUC4, MUC5AC, MUC5B, MUC6, MUC7, MUC9, and MUC21 proteins was examined immunohistochemically and their levels were semi- quantified in 80 IIP-associated LADCs and 106 non-IIP LADCs. LADCs were divided into low and high expressers based on thresholds obtained from the receiver operating characteristic (ROC) curves of each mucin protein. Low expressers of MUC1, MUC7, and MUC21 and high expressers of MUC4, MUC5AC, MUC5B, and MUC9 were dominant in the IIP group. Multivariate analyses confirmed that the correlations between mucin expression profiles and IIP-associated LADCs were independent of putative confounding factors, such as smoking, gender, histological types, and cytological types. Thus, the expression profiles of these mucin proteins significantly differed between the IIP and non-IIP groups. IIP-associated LADCs appear to have unique cellular differentiation features and they may develop through a distinct histogenetic pathway. This is the first study to demonstrate that IIP-associated LADCs have unique mucin expression profiles.es
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dc.format.extent12es
dc.identifier.citationHistology and Histopathology Vol. 34, nº 11 (2019)
dc.identifier.doihttps://doi.org/10.143670/HH-18-114
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/124843
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMucines
dc.subjectImmunohistochemistryes
dc.subjectInterstitial pneumoniaes
dc.subjectLunges
dc.subjectAdenocarcinomaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleUnique expression profiles of mucin proteins in interstitial pneumonia-associated lung adenocarcinomases
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34,nº11 (2019)