Publication: Expression of the serine protease, matriptase, in breast ductal carcinoma of Chinese women: Correlation with clinicopathological parameters
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Date
2007
Authors
Jin, J.S. ; Cheng, T.F. ; Tsai, W.C. ; Sheu, L.F. ; Chiang, H. ; Yu, C.P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Matriptase is a serine protease expressed by
cells of surface epithelial origin, including epithelial
breast tumor cells. Matriptase cleaves and activates
proteins implicated in the progression of cancer and
represents a potential prognostic and therapeutic target.
The aim of this study was to examine matriptase
expression in breast tumors of Chinese women and to
identify its clinicopathological correlations.
Immunohistochemical analysis of matriptase was
performed in tissue microarrays of 251 breast tumors
including 30 fibroadenomas, 59 ductal carcinomas in
situ (DCIS), 38 grade I invasive ductal carcinomas
(IDC), 79 grade II IDC, and 45 grade III IDC. The
matriptase scores were significantly higher in the tumors
than their non-tumor counterparts (178±12 for
fibroadenoma; 275±11 for DCIS; 299±10 for grade I
IDC; 251±10 for grade II IDC; and 314±11 for grade III
IDC). In cases of IDC, matriptase scores were
significantly correlated with tumor staging and nodal
staging. Our findings demonstrate that matriptase is
over-expressed in breast ductal carcinoma of Chinese
women. It therefore may be a good biomarker for
diagnosis and treatment of malignant breast tumors
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