Publication: Molecular and cellular basis of tissue remodeling during amphibian metamorphosis
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Date
1999
Authors
Su, Y. ; Damjanovski, S. ; Shi, Y. ; Shi, Y.B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Amphibian metamorphosis involves
systematic transformations of various tadpole organs1
tissues. Three major types of changes take place during
this process. These are remodeling, resorption, and de
novo development, all of which appear to involve both
cell proliferation and apoptosis (programmed cell death).
All metamorphic changes are controlled by thyroid
hormone (T3) and are organ-autonomous. Recent studies
using primary cell cultures and a stably transformed cell
line from tadpole tissues have implicated that T3 induces
apoptosis cell-autonomously. This T3-induced,
metamorphosis-associated apoptosis is similar to cell
death in other animal species and involves similar cell
death executioners. Both the activation of these
executioners and the pathways leading to cell
proliferation and differentiation are believed to be
through transcriptional regulation by T3 receptors (TRs).
TRs can activate or repress target gene transcription
depending upon the presence or absence of T3,
respectively. Many direct T3-response genes have been
isolated and found to encode a variety of proteins that
can affect both intra- and extra-cellular events. The
determinations of the identities of these response genes
through sequence analyses and studies on their expression profiles during development have provided
strong clues toward their roles in metamorphosis.
However, future studies using organ and cell culture
systems andlor transient or stable transgenic
technologies are required to understand how these genes
transduce the T3 signal to activate the downstream cell
death and proliferation/differentiation pathways.
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