Publication:
Age-related changes in fatty acid profile and locomotor activity rhythms in Nothobranchius korthausae

Simple item page
dc.contributor.authorLucas-Sanchez, A
dc.contributor.authorAlmaida Pagán, Pedro Francisco
dc.contributor.authorMadrid, Juan A
dc.contributor.authorCosta, J. de
dc.contributor.authorMendiola, P
dc.contributor.departmentFisiología
dc.date.accessioned2024-06-20T10:59:45Z
dc.date.available2024-06-20T10:59:45Z
dc.date.issued2011-08-28
dc.description© 2011 Elsevier Inc. This document is the Published version of a Published Work that appeared in final form in Experimental Gerontology. To access the final edited and published work see https://doi.org/10.1016/j.exger.2011.08.009
dc.description.abstractThe life cycle of Nothobranchius korthausae, a Cyprinodontiformes fish, was studied in our laboratory to characterise the ageing process. Some morphological changes, such as spine curvature, skin colour, and fin and eye appearance are described. Growth and survival curves reflected a fast life cycle with rapid initial growth until 4 weeks of age, after which the fish grew more slowly before reaching their final size in week 40. Senescence onset was established at week 48 with a decrease in spawn size and viability and a general decline in the animal's appearance (weight and colouration losses, caudal fin degradation, and cataractogenesis). The fatty acid composition changed with age,with high unsaturation in the adult stage as reflected by a high peroxidation index, a condition that is associated with high susceptibility to oxidative damage if elevated reactive oxygen species (ROS) production occurs. Senescent fish had an increase in monounsaturated fatty acid proportions and a lower peroxidation index (226.5±19.7 in adults versus 120.2±19.1 in senescent fish, Pb0.05). The circadian system, as reflected by locomotor activity rhythms, showed noticeable changes with age. Twenty-four-week-old fish (adults) had a robust diurnal rhythm that showed a decrease in total activity, an increase in rhythmfragmentation, and a fall in amplitude and regularity with age. Changes were clearly reflected in the Circadian Function Index variations (0.56, 0.47 and 0.25 at 24, 48 and 72 weeks of age, respectively). In conclusion, N. korthausae appears to be a species with appropriate characteristics for ageing studies because it manifests clear signs of progressive ageing. Comparing species of Nothobranchius genus with different lifespans may be useful for increasing our understanding of the ageing process.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationExperimental Gerontology, 2011, Vol. 46, N. 12, pp. 970–978
dc.identifier.doihttps://doi.org/10.1016/j.exger.2011.08.009
dc.identifier.issnPrint: 0531-5565
dc.identifier.urihttp://hdl.handle.net/10201/142491
dc.languageenges
dc.publisherElsevieres
dc.relationThis project was funded by the Seneca Foundation (12005/PI/09), the Instituto de Salud Carlos III (RETICEF, RD06/0013/0019) and the Ministerio de Educación y Ciencia (BFU2007-60658/BFI).es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0531556511002087#aep-acknowledgment-id23es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectNothobranchius korthausaees
dc.subjectAgeing
dc.subjectFatty acids
dc.subjectLocomotor activity
dc.subjectCircadian rhythms
dc.titleAge-related changes in fatty acid profile and locomotor activity rhythms in Nothobranchius korthausaees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
5.Lucas-Sanchez et al., 2011.pdf
Size:
468.53 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos