Publication: What are the germ cell phenotypes from infertile men telling us about spermatogenesis?
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Date
1999
Authors
Escalier, D.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Drosophila mutants for known genes and
those obtained following germline genetic engineering in
mice have led to the identification of genes involved in
the initiation and the maintenance of spermatogenesis
and in the different steps of meiosis. Mutants allow the
definition of meiosis-specific checkpoint controls that
ensure the transmission of complete and undamaged
genetic information. They reveal what spermatogenesis
events are interdependent. In the light of these data, an
attempt is made to define which events of spermatogenesis
could be defective in some well-defined human
spermatogenesis failures. They appear to be good
models to study the decouplages of spermatogenesis
events, the morphogenetic relationships between germ
cell structures and the occurrence of pleiotropic sperm
phenotypes. It is discussed whether a germ cell with a
normal phenotype can transmit a non-functional gene
involved in spermatogenesis and how homologous genes
can lead to different germ cell phenotypes depending on
the species.
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